Results 81 to 90 of about 5,813,857 (293)
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Principle of Analogy [PDF]
, 2006 The Principle of Analogy. ABSTRACT. Sceptics question whether ‘distinctively human’ predicates such as ‘just’, ‘loving’ and ‘powerful’ can intelligibly be attributed to a divine being.
Bunting, Harry
core
Localization principle and relaxation
, 2013 Relaxation theorems for multiple integrals on W^{1,p}(\Omega;\RR^m), where p\in]1,\infty[, are proved under general conditions on the integrand L:\MM\to[0,\infty] which is Borel measurable and not necessarily finite.
Mandallena, Jean-Philippe
core +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
On a generalised bootstrap principle
, 1993 The S-matrices for non-simply-laced affine Toda field theories are considered in the context of a generalised bootstrap principle. The S-matrices, and in particular their poles, depend on a parameter whose range lies between the Coxeter numbers of dual ...
Arinshtein +34 more
core +2 more sources
Notre Dame Journal of Formal LogicWe introduce the split principles and show that they bear tight connections to large cardinal properties such as inaccessibility, weak compactness, subtlety, almost ineffability and ineffability, as well as classical combinatorial objects such as Aronszajn trees, Souslin trees or square principles.
Fuchs, Gunter, Minden, Kaethe
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The reasonableness among the rule-making principles
Проблеми Законності, 2013 The article describes the principles on which the process of creation of the law is based. The role of reasonableness as rule-making requirement is explained.
К. О. Мандрікова
doaj +1 more source