Results 41 to 50 of about 1,174,031 (247)

ISIS’s Interpretation of the Holy Quran A study for the main cover line of the first and second issue of the Dabiq magazine

open access: yesZanco Journal of Humanity Sciences, 2021
This research sheds light on ISIS’s interpretation of the Holy Qur’an by, within studying the first and second issue cover lines of Dabiq magazine. ISIS utilizes Qur’anic verses to spread their Ideologies, showing it as a source of violence, which has ...
Farooq Omar Ahmed
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Two‐tone suppression between the ultrasounds above and within the hearing range in mice

open access: yesExperimental Physiology
Hearing range differs among various species. Ultrasound, which is audible to microbats and dolphins, is inaudible to humans through air conduction. However, it can create an auditory sensation when the stimulation is transmitted through the temporal bone.
Noriko Nagase   +7 more
doaj   +1 more source

Determination of Father in Artificial Insemination Based on Jurisprudence and Islamic Law [PDF]

open access: yesپژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
The recognition of parentage is one of the important issues in Shari'a, especially in the cases where there is doubt. Artificial insemination between two foreigners is a suspicious example that is criticized in two terms of imperatives and positive rules.
Ezat Sadat Mousavi Dorcheh   +2 more
doaj  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Individual innovativeness levels and levels of medical artificial intelligence readiness among nursing students: a cross-sectional and correlational study

open access: yesBMC Medical Education
Aim This study, aimed to determine the individual innovativeness levels of nursing students and their readiness levels for medical artificial intelligence and the relationship between these two variables.
Şeyda Kazanç   +2 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

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