Prion protein - Open Access .click

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2003
Protein function is often observed directly following protein isolation, or is deduced by loss of function following gene knockout or by analogy with proteins of known function and similar amino acid sequence. None of these is true in the case of prion proteins because aside from the association with the pathogenesis of the spongiform encaphalopathies,
Ian M. Jones, David R. Brown
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The function of the cellular prion protein in health and disease

Acta Neuropathologica, 2018
J. Watts, Matthew E. C. Bourkas, H. Arshad +2 more
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Prion Protein Disease and Neuropathology of Prion Disease

Neuroimaging Clinics of North America, 2008
Human prion diseases, in common with other neurodegenerative diseases, may be sporadic or inherited and are characterized by the accumulation of cellular proteins accompanied by neuronal death and synaptic loss. Prion diseases are, however, unique in being transmissible.
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Cell Biology of Prion Protein

2017
Cellular prion protein (PrPC) is a mammalian glycoprotein which is usually found anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. The precise function of PrPC remains elusive but may depend upon its cellular localization. PrPC misfolds to a pathogenic isoform PrPSc, the causative agent of neurodegenerative prion diseases.
SARNATARO, DANIELA, PEPE, ANNA, ZURZOLO, CHIARA +2 more
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Prion proteins and prion diseases [PDF]