Results 211 to 220 of about 11,906,471 (302)

Detection of Viable Nannizziopsis guarroi in Housing Environments Prior to Dermatological Lesion Development in Bearded Dragons (Pogona vitticeps). [PDF]

Animals (Basel)
Dalen JP, Wong AD, Adamovicz L, Liszka NC, Keller KA.   +4 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Aspergillus Serology Predicts Relapse in Chronic Pulmonary Aspergillosis: Implications for Personalised Follow-Up Strategies. [PDF]

Mycoses
Choyce A, Colombo S, Cyriac C, Alasfour A, Ng WK, Amphlett L, Kosmidis C.   +6 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Latent thermodynamic flows: unified representation learning and generative modeling of temperature-dependent behaviors from limited data. [PDF]

Chem Sci
Qiu Y, John R, Herron L, Tiwary P.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Prior Concussions and Risk of Disability for Patients After a Motor Vehicle Crash.

JAMA Netw Open
Redelmeier DA, Bhatt V, Drover SSM.
europepmc   +1 more source

Nationwide Survival Impact of Bevacizumab Under National Reimbursement for Advanced Cervical Cancer in South Korea. [PDF]

Cancers (Basel)
Kim J, Jang J, Tewari KS, Kim KS, Kang HC, Kang S.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of prior therapy on the clinical activity of imetelstat in patients with transfusion-dependent, ESA-relapsed or -refractory/-ineligible LR-MDS. [PDF]

Blood Cancer J
Komrokji RS, Santini V, Zeidan AM, Sekeres MA, Fenaux P, Raza A, Mittelman M, Thépot S, Buckstein R, Germing U, Madanat YF, Díez-Campelo M, Valcárcel D, Jonášová A, Dougherty S, Shah S, Xia Q, Sun L, Navada S, Feller F, Savona MR, Platzbecker U.   +21 more
europepmc   +1 more source