Results 91 to 100 of about 1,157,980 (306)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Including the excluded: an evaluation of a sexual health promotion capacity building intervention among specialist homelessness services in New South Wales

International Journal for Equity in Health
Background In Australia, just as most other settings, existing programs focusing on sexual and reproductive health of young people largely occur within formal school and clinical settings, thereby limiting accessibility to young people experiencing ...
Sylvester Okeke, Eliza Basheer, Sarah Smith, Libby Campbell, Rochelle Avasalu, Anni Slater, Grace Robin, Mikayla Napier, Megan Hall, Nathan Ryder, Limin Mao   +10 more
doaj   +1 more source

Policy framework for updating and utilizing poverty data using MULTIPOL method in Bekasi Regency, Indonesia [PDF]

Decision Science Letters
Poverty is a complex and multidimensional social problem faced by almost all countries including Indonesia. Poverty alleviation efforts require accurate and up-to-date data to ensure that social welfare programs can effectively run and target ...
Beny Cahyadie, Bambang Juanda, Akhmad Fauzi, Rilus A. Kinsen   +3 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Development of digital self-management support for breast cancer survivors: ensuring evidence-based approaches and patient engagement from concept to implementation☆

ESMO Real World Data and Digital Oncology
Background: This study aimed to develop digital self-management programs incorporating evidence-based behavioral interventions to address the physical and psychosocial challenges faced by breast cancer survivors (BCS).
M.A. Franzoi, E. Martin, A.R. Ferreira, F. Jacq, E. Gillanders, A. Di Meglio, I. Vaz-Luis   +6 more
doaj   +1 more source

Concordance of Length and Contents of Continuing Medical Education Programs with Educational Demands of Practicing GPs in Khuzestan Province [PDF]

مجله ایرانی آموزش در علوم پزشکی, 2007
Introduction: Assessing educational needs and prioritizing them is the first step in planning. Evaluation of current Continuing Medical Education (CME) programs according to the general physicians' points of view is essential for quality improvement and ...
Abdolhossein Shakurnia, Hossein Elhampour, Tayebeh Marashi, Shahin Heidari Soureshjani   +3 more
doaj  

PRIORITAS PENGGUNAAN DANA DESA DALAM BIDANG PEMBERDAYAAN MASYARAKAT DESA TEPIAN BATANG KECAMATAN TANAH GROGOT KABUPATEN PASER TAHUN 2020 [PDF]

Priority use of village funds is a choice of activities that take precedence and priority over other activity options to be financed with village funds.
Ammar, Muhammad Naufal
core  

Key Drivers of Successful Implementation of an Employee Suggestion-Driven Improvement Program [PDF]

, 2012
Service organizations frequently implement improvement programs to increase quality. These programs often rely on employees’ suggestions about improvement opportunities.
Singer, Sara Jean, Tucker, Anita Lynn
core  

Scientific priorities of new environmental program

Journal of Geography and Environmental Management, 2020
The article discusses the scientific priorities in the preparation of the new environmental education program developed by an international team of scientists and university professors, as well as employers. The priorities of research in the field of environmental science are concentrated in 17 Goals of Sustainable Development, which determine the ...
openaire   +1 more source