Results 51 to 60 of about 1,157,980 (306)

MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou, Regina Kubica, Karen Fischhuber, Jasmin Beygo, Madlen Reschke, Petra Ritter‐Sovinz, Eva Biewald, Petra Ketteler, Dietmar Lohmann, Deniz Kanber   +9 more
wiley   +1 more source

A Spatial Multi-Criteria Framework to Define Priorities in Wildfire Management Programs

Fire
The intensification of wildfires in Portugal has highlighted the urgent need for technical tools capable of supporting more effective risk mitigation decisions.
Ana Gonçalves, Diogo M. Pinto, Sandra Oliveira, José Luís Zêzere   +3 more
doaj   +1 more source

The city as a refuge for insect pollinators [PDF]

, 2016
Urban ecology research is changing how we view the biological value and ecological importance of cities. Lagging behind this revised image of the city are natural resource management agencies’ urban conservation programs that historically have invested ...
Asah, Baldock, Bates, Benton, Burr, Cane, Cariveau, Collins, Cook, Deguines, Ehrlich, Frankie, Frankie, Frankie, Frankie, Garbuzov, Gardiner, Geslin, Gill, Goddard, Goulson, Goulson, Goulson, Grove, Gunnarsson, Hanley, Hansen, Harrison, Heezik, Hennig, Hernandez, Jaffe, Kleijn, Larson, Lowenstein, Luck, Matteson, Matteson, Matteson, McCleery, McFrederick, McKinney, McKinney, Muratet, Ollerton, Osborne, Pardee, Pejchar, Peterson, Pickett, Pleasants, Potts, Ramalho, Sanderson, Saure, Scheper, Sheffield, Shwartz, Silva Mouga, Simon-Delso, Sirohi, Sluijs, Threlfall, Tommasi, Tonietto, Vanbergen, Verboven, Whitehorn, Williams, Williams, Winfree   +70 more
core   +7 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Typology of Cluster Development Agents' Viewpoints with a Focus on Performance Determinants [PDF]

چشم‌انداز مدیریت صنعتی, 2013
Nowadays developing industrial clusters has been emerged as an important regional development approach and turned attentions of many researchers and propels governments to develop and implement cluster development programs.
Akbar Alem Tabriz, Hassan Farsijani, Farhad Farzad, Seyed Hadi Mirghaderi   +3 more
doaj  

Astro2020 Science White Paper: Triggered High-Priority Observations of Dynamic Solar System Phenomena [PDF]

, 2019
Unexpected dynamic phenomena have surprised solar system observers in the past and have led to important discoveries about solar system workings. Observations at the initial stages of these events provide crucial information on the physical processes at ...
Bell, James F., Benecchi, Susan, Cartwright, Richard, Chanover, Nancy, Conrad, Al, de Kleer, Katherine, de Pater, Imke, Fry, Patrick, Gaidos, Eric, Giles, Rohini, Greathouse, Thomas, Hammel, Heidi, Hendrix, Amanda, Holler, Bryan, Lucas, Michael, Luszcz-Cook, Statia, Mandt, Kathleen, Meech, Karen, Milam, Stefanie, Nixon, Conor, Orton, Glenn, Otarola, Angel, Pinilla-Alonso, Noemi, Retherford, Kurt, Rivkin, Andy, Sayanagi, Kunio, Schwamb, Megan E., Simon, Amy, Tiscareno, Matthew, Trilling, David, Veillet, Christian, Verbiscer, Anne, Wong, Michael H.   +32 more
core   +1 more source

Efficiency, profitability and carbon footprint of different management programs under no-till to control herbicide resistant Papaver rhoeas [PDF]

, 2020
The present work examines the effects of different integrated weed management (IWM) programs on multiple herbicide-resistant Papaver rhoeas populations in terms of effectiveness, profitability and carbon footprint.
Recasens i Guinjuan, Jordi, Royo-Esnal, Aritz, Torra Farré, Joel, Valencia-Gredilla, Francisco   +3 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Collective Action and Responses to Poor‐Quality Recycling in St. John’s [PDF]

, 2009
This paper discusses the lack of proper recycling programs in St John’s, NL and explains the relevance of collective action and rational choice theories in addressing the matter. The city has done a poor job of implementing proper recycling programs, and
Williams, Mark
core