Results 81 to 90 of about 1,157,980 (306)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The natural resources of San Diego Bay; Their status and future [PDF]
, 1973 The study of the natural resources of San Diego Bay is a part of a high priority inventory and assessment program conducted by the Department of Fish and Game.
Browning, Bruce M. +2 more
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
ON THE FORMATION OF THE STRATEGY OF POPULATION QUALITY OF LIFE IMPROVEMENT [PDF]
Экономика региона, 2008 This article is about a role of priority national projects in maintenance of perfection of population quality improvement in the regions. The supreme state problems in this direction which effective reproduction and use of labour potential should serve ...
T.V. Polkova
doaj
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2016 The necessity of search of the effective individual programs for rehabilitation in patients with neuromyelitis optica spectrum disorders (NMOSDs) is recognized by majority of authors.
V. S. Krasnov +3 more
doaj +1 more source
Legal and Judicial Development: The Role of Civil Society in the Reform Process [PDF]
, 2000 While many governments are undertaking reforms that aim to improve judicial and legal systems, there is a growing realization that civil society plays a vital and even necessary role in these efforts.
Bakolias, Maria
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Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Methodical Recommendations about Ranging of Target Programs About Priority of Their Financing From the State Budget Методические рекомендации по ранжированию целевых программ по приоритетности их финансирования из Государственного бюджета [PDF]
Problemi Ekonomiki, 2012 In article the program and target method, as one of the most effective methods of implementation of expenses of budgets around the world is considered. Information on implementation of the state target programs in Ukraine is analysed. Considerable excess
Kizim Nikolay A., Fedenko Galina M.
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Why Family Planning and Reproductive Health are Critical to the Well-Being of Youth [PDF]
, 2009 An unprecedented number of young people are entering their reproductive years, most of whom live in the developing world. U.S. policy makers should assist in effortS to ensure that youth worldwide are able to make informed decisions about their sexuality
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