Results 111 to 120 of about 203,920 (318)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A registered re-examination of the effects of leftward prism adaptation on landmark judgements in healthy people

, 2022
Robert D. McIntosh, Antonia F. Ten Brink, A.G. Mitchell, Hannah Jones, Nan Peng, Melissa Thye, Janet H. Bultitude   +6 more
openalex   +2 more sources

Ultra-dispersive adaptive prism

, 2007
We have experimentally demonstrated an ultra-dispersive optical prism made from coherently driven Rb atomic vapor. The prism possesses spectral angular dispersion that is six orders of magnitude higher than that of a prism made of optical glass; it is the highest spectral angular dispersion that has ever been shown (such angular dispersion allows one ...
Sautenkov, Vladimir A., Li, Hebin, Rostovtsev, Yuri V., Scully, Marlan O.   +3 more
openaire   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Improvement of Navigation and Representation in Virtual Reality after Prism Adaptation in Neglect Patients

Frontiers in Psychology, 2017
Prism adaptation (PA) is responsible for an expansion of sensori-motor after-effects to cognitive domains for patients with spatial neglect. One important question is whether the cognitive after-effects induced by PA may also concern higher aspects of ...
Bertrand Glize, Bertrand Glize, Bertrand Glize, Marine Lunven, Marine Lunven, Marine Lunven, Yves Rossetti, Patrice Revol, Sophie Jacquin-Courtois, Sophie Jacquin-Courtois, Evelyne Klinger, Evelyne Klinger, Pierre-Alain Joseph, Pierre-Alain Joseph, Gilles Rode, Gilles Rode, Gilles Rode   +16 more
doaj   +1 more source

Learning policies through argumentation-derived evidence (extended abstract) [PDF]

, 2010
(c) IFAAMASPublisher ...
Emele, Chukwuemeka D, Guerin, Frank, Norman, Timothy J, Parsons, Simon   +3 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Auditory-motor adaptation: induction of a lateral shift in sound localization after biased immersive virtual reality training

Frontiers in Cognition
IntroductionSensorimotor adaptation has often been studied in the visual modality through the Prism Adaptation (PA) paradigm. In this paradigm, a lateral shift in visual pointing was found after wearing prismatic goggles.
Alma Guilbert, Tristan-Gael Bara, Tifanie Bouchara   +2 more
doaj   +1 more source