Results 81 to 90 of about 203,920 (318)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Limited Plasticity of Prismatic Visuomotor Adaptation
i-Perception, 2017 Movements toward an object displaced optically through prisms adapt quickly, a striking example for the plasticity of neuronal visuomotor programs. We investigated the degree and time course of this system’s plasticity.
Karoline Spang +2 more
doaj +1 more source
Perceptual Calibration of F0 Production: Evidence from Feedback Perturbation [PDF]
, 2000 Hearing one’s own speech is important for language learning and maintenance of accurate articulation. For example, people with postlinguistically acquired deafness often show a gradual deterioration of many aspects of speech production.
Jones, Jeffery A., Munhall, Kevin
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Big Data Analytics for QoS Prediction Through Probabilistic Model Checking [PDF]
, 2014 As competitiveness increases, being able to guaranting QoS of delivered services is key for business success. It is thus of paramount importance the ability to continuously monitor the workflow providing a service and to timely recognize breaches in the ...
Cicotti, Giuseppe +3 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Senior Thesis ST 2011-02 [PDF]
, 2010 Agriculture in the Arctic is often limited by the low receipt of heat energy, which is often measured in growing degree days (GDD). With the advent of increasingly powerful climate modeling, projection and downscaling techniques, it is becoming ...
Hatch, Ellen W.
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
On the Mechanics of Immediate Corrections and Aftereffects in Prism Adaptation
Vision, 2017 Prisms laterally shifting the perceived visual world cause arm movements to deviate from intended targets. The resulting error—the direct effect—both for pointing and throwing movements, usually corresponds to only around half of the prism’s optical ...
Klaudia Pochopien +3 more
doaj +1 more source
Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]
, 2013 Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S. +5 more
core +3 more sources