Results 291 to 300 of about 1,939,766 (365)

Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis

Advanced Science, EarlyView.
Chchd10 is a novel regulator of adipose tissue (AT) homeostasis upon excess energy intake. Rapid Chchd10 reduction in response to high‐fat diet induction promotes adipogenesis in subcutaneous AT to store excess energy. On the other hand, sustained Chchd10 reduction protects visceral AT from 4‐HNE‐induced adipocyte dysfunction, attenuating the ...
Xiaoping Wu, Zixuan Zhang, Jingjing Li, Jiuyu Zong, Lufengzi Yuan, Lingling Shu, Lai Yee Cheong, Xiaowen Huang, Mengxue Jiang, Zhihui Ping, Aimin Xu, Ruby L.C. Hoo   +11 more
wiley   +1 more source

Federated Learning-Based Predictive Traffic Management Using a Contained Privacy-Preserving Scheme for Autonomous Vehicles. [PDF]

Sensors (Basel)
Alqubaysi T, Asmari AFA, Alanazi F, Almutairi A, Armghan A.   +4 more
europepmc   +1 more source

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, EarlyView.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source

Geniposidic Acid Targeting FXR “S332 and H447” Mediated Conformational Change to Upregulate CYPs and miR‐19a‐3p to Ameliorate Drug‐Induced Liver Injury

Advanced Science, EarlyView.
Drug abuse exacerbates cholesterol and bile acids burden, causing liver injury. Geniposidic acid targets FXR Ser332 and His447, together with SRC2‐3 recruitment and activated FXR nuclear translocation. Geniposidic acid‐activated FXR can upregulate CYPs to accelerate bile acids clearance and activate miR‐19a‐3p to suppress LXR‐mediated cholesterol ...
Minqi Fan, Yuanhang Xu, Bingxin Wu, Jiachan Long, Caihong Liu, Zuhui Liang, Rong Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Artificial intelligence, data sharing, and privacy for retinal imaging under Brazilian Data Protection Law. [PDF]

Int J Retina Vitreous
Nakayama LF, Zago Ribeiro L, Malerbi FK, Regatieri CS.   +3 more
europepmc   +1 more source

Advances in Nano‐Immunomodulatory Systems for the Treatment of Acute Kidney Injury

Advanced Science, EarlyView.
Based on the biodegradability and the immunological reactiveness, IMNs can be broadly classified into four categories. The first category includes types of biologically derived materials that cause immunomodulatory action and biodegradability like nanoparticles of cell membranes, extracellular vesicles, and exosomes.
Chenli Zhang, Zeli Xiang, Pengfei Yang, Ling Zhang, Jun Deng, Xiaohui Liao   +5 more
wiley   +1 more source

Publishing neural networks in drug discovery might compromise training data privacy. [PDF]

J Cheminform
Krüger FP, Östman J, Mervin L, Tetko IV, Engkvist O.   +4 more
europepmc   +1 more source

The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies

Advanced Science, EarlyView.
This work explores the process of morning awakening of the human brain using polysomnography paired with simultaneous stereo‐electroencephalography, a method that provides high spatial and temporal resolution for examining brain activity. Awakening is characterized by an increase in high‐frequency spectral power and connectivity.
Tamir Avigdor, Guoping Ren, Chifaou Abdallah, François Dubeau, Christophe Grova, Birgit Frauscher   +5 more
wiley   +1 more source

Privacy violations in election results. [PDF]

Sci Adv
Kuriwaki S, Lewis JB, Morse M.
europepmc   +1 more source

An Anti‐CD147 Antibody−Drug Conjugate Mehozumab‐DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey

Advanced Science, EarlyView.
Antibody‐drug conjugates are among the fastest‐growing drugs in oncology. It combines the potent killing activity of small molecular drugs and the high specific targeting of antibody drugs. Our in vitro and in vivo studies suggest that anti‐CD147 ADC Mehozumab‐DM1 potently inhibits hepatocellular carcinoma, and combining CD147‐ADCs and targeted therapy
Wan Huang, Liping Zhong, Ying Shi, Qingzhi Ma, Xiangmin Yang, Hongmei Zhang, Jing Zhang, Ling Wang, Kun Wang, Jingzhuo Li, Jie Zou, Xu Yang, Liu Yang, Qingmei Zeng, Lin Jing, Zhi‐Nan Chen, Yongxiang Zhao   +16 more
wiley   +1 more source