Results 211 to 220 of about 2,194 (257)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Contratos de licença de uso de software “Enterprise Resource Planning” e a Lei Geral de Proteção de Dados: a reestruturação contratual com base na metodologia Privacy by Design

Theodoro Luiz Liberati Silingovschi
openalex   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

MR‐DELTAnet: A Longitudinal MRI‐Transformer Model Predicting Pathological Complete Response and Revealing Immune Microenvironment via scRNA‐seq in Locally Advanced Rectal Cancer

Advanced Science, EarlyView.
The MR‐DELTAnet model utilizes longitudinal MRI to predict treatment response after neoadjuvant chemoradiotherapy in locally rectal cancer patients, accurately identifying patients likely to achieve pathological complete response for personalized management.
Wuteng Cao, Huaxian Chen, Jiao Li, Yihui Zheng, Liqing Xie, Guozhong Xiao, Zeyan Wang, Fen Yuan, Junhong Chen, Chongbao Sun, Jing Dai, Jinping Zeng, Xinhua Wang, Lei Wu, Hongcheng Lin   +14 more
wiley   +1 more source

Stress‐Induced Melting Controlled Failure Mechanisms of Methane Hydrate

Advanced Science, EarlyView.
We study methane hydrate via nanoindentation and nuclear magnetic resonance (NMR), finding its regional melting and mechanical properties, challenging existing views on hydrogen‐bonded crystals. Abstract Methane hydrate, a kind of nonstoichiometric crystalline, attracted worldwide attentions as a promising substitute energy. Its Dissociation is thought
Yanlong Li, Yuan Zhou, Zhengcai Zhang, Minhui Qi, Yajuan Zhang, Yujing Jiang, Yunkai Ji, Qingguo Meng, Yongfu Sun, Nengyou Wu   +9 more
wiley   +1 more source

Adding Privacy Protection to Distributed Software Systems

Proceedings of the 14th International Joint Conference on e-Business and Telecommunications, 2017
openaire   +1 more source

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Software Defined Privacy

2016 IEEE International Conference on Cloud Engineering Workshop (IC2EW), 2016
Cloud Computing has been one of the most fascinating and influential technologies in recent years and has literally revolutionised the way we access computing resources by providing a virtually unlimited amount of resources instantaneously. Despite this seemingly amazing breakthrough, there are still some clouds on the horizon, preventing the paradigm ...
Florian Kemmer, Christoph Reich, Martin Knahl, Nathan Clarke   +3 more
openaire   +1 more source

Privacy Petri Net and Privacy Leak Software

Journal of Computer Science and Technology, 2015
Private information leak behavior has been widely discovered in malware and suspicious applications. We refer to such software as privacy leak software (PLS). Nowadays, PLS has become a serious and challenging problem to cyber security. Previous methodologies are of two categories: one focuses on the outbound network traffic of the applications; the ...
Le-Jun Fan, Yuan-Zhuo Wang, Jing-Yuan Li, Xue-Qi Cheng, Chuang Lin   +4 more
openaire   +1 more source

Privacy by designers

Proceedings of the 40th International Conference on Software Engineering, 2017
Privacy by design (PbD) is a policy measure that guides software developers to apply inherent solutions to achieve better privacy protection. For PbD to be a viable option, it is important to understand developers' perceptions, interpretation and practices as to informational privacy (or data protection).
Irit Hadar, Tomer Hasson, Oshrat Ayalon, Eran Toch, Michael Birnhack, Sofia Sherman, Arod Balissa   +6 more
openaire   +1 more source