Results 261 to 270 of about 643,939 (333)

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

Advanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao, Jing Wang, Bei Chen, Jinhui Yang, Fangyu Wu, Chunyao Zhou, Yifei Zhang, Zhiquan Yang, Dingyang Liu, Lei Tian, Jianhua Yu, Fei Han, Yongxiang Tang, Li Feng, Shuo Hu   +14 more
wiley   +1 more source

ClipKIT in the browser: fast online trimming of multiple sequence alignments for phylogenetics. [PDF]

Nucleic Acids Res
Steenwyk JL, Loucks JT, Buida TJ.
europepmc   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Assessment of implementation challenges of electronic medical record in Yekatit 12 hospital medical college. [PDF]

PLoS One
Mamae AA, Mamo E.
europepmc   +1 more source

Artificial Intelligence‐Assisted Urine Cytology for Noninvasive Detection of Muscle‐Invasive Urothelial Carcinoma: A Multi‐Center Diagnostic Study with Prospective Validation

Advanced Science, EarlyView.
Accurate preoperative detection of muscle‐invasive urothelial carcinoma (MIUC) is crucial for clinical decision‐making. This study developed PUCAS‐M, an artificial intelligence (AI) model that analyzes urine cytology to assist in differentiating MIUC from non‐MIUC.
Runnan Shen, Fan Jiang, Xiaowei Huang, Guibin Hong, Yun Luo, Huan Wan, Ye Xie, Mengyi Zhu, Yun Wang, Bohao Liu, Ping Qin, Yahui Wang, Haoxuan Wang, Hongkun Yang, Zhen Lin, Rui Chen, Nengtai Ouyang, Jian Huang, Tianxin Lin, Shaoxu Wu   +19 more
wiley   +1 more source

Clinical performance of an interactive platform based on artificial intelligence in ophthalmology: experience in a third-level reference center. [PDF]

Front Med (Lausanne)
Armadá-Maresca F, Capote-Díaz M, Cidad-Betegón MDP, Cordero-Ros RM, Martínez-Godoy L, Vázquez-Colomo P, Laín-Olia B, Songel-Sanchís B, Caminos-Melguizo A, Baoud-Ould-Haddi I.   +9 more
europepmc   +1 more source

Adding Privacy Protection to Distributed Software Systems

Proceedings of the 14th International Joint Conference on e-Business and Telecommunications, 2017
openaire   +2 more sources

High‐Speed Design of Multiplexed Meta‐Optics Enabled by Physics‐Driven Self‐Supervised Network

Advanced Science, EarlyView.
A physics‐driven self‐supervised network (PDSS‐Net) is proposed for high‐speed, iteration‐free design of multiplexed meta‐optics. By learning a direct mapping from holographic targets to all meta‐atom structures, PDSS‐Net achieves a 1000× speedup over traditional optimization methods in designing 2K RGB meta‐holograms.
Yuqing He, Sheng Ye, Yue Han, Mingna Xun, Qiang Li, Ruiqi Wang, Qihuang Gong, Yan Li   +7 more
wiley   +1 more source

Fusion of Personalized Federated Learning (PFL) with Differential Privacy (DP) Learning for Diagnosis of Arrhythmia Disease. [PDF]

PLoS One
Bokhari SM, Sohaib S, Shafi M.
europepmc   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
wiley   +1 more source