Results 51 to 60 of about 2,317,055 (299)

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Exploring the determinants of engagement in the context of mHealth and social media among young people: A systematic literature review

Digital Health
Objectives Integration of social media (SM) with mobile health (mHealth) platforms presents significant potential to address the persistent challenge of disengagement in digital health interventions among young people.
Moses Private Mbetse, Bester Chimbo, Lario Malungana   +2 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Público, privado e o indivíduo no novo capitalismo

Tempo Social, 2000
O presente texto procura discutir algumas das manifestações que caracterizam o indivíduo na sociedade brasileira contemporânea, tomando-se como ponto de partida as concepções de vida pública e vida privada.
Pedro Fernando Bendassolli
doaj   +1 more source

Evaluation of Varicocele Frequency in Adolescents in the City of Isfahan [PDF]

International Journal of Fertility and Sterility, 2007
Background Although varicocele can be treated, it is considered as one of the most common causes of infertility. This study was performed in order to estimate prevalence of varicocele in adolescents aging 12-14 years in the city of Isfahan.
Homayoun Abbasi, Amir Ghanbarian, Saeid Salimi Khoozani, Mohammad Hossein Nasr-Esfahani   +3 more
doaj   +1 more source

Open Source Software and the "Private-Collective" Innovation Model: Issues for Organization Science

Organ. Sci., 2003
Currently, two models of innovation are prevalent in organization science. The "private investment" model assumes returns to the innovator result from private goods and efficient regimes of intellectual property protection.
E. Hippel, G. Krogh
semanticscholar   +1 more source

Sex Differences in Medication Discontinuation in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Objective We examined sex differences in medication discontinuation among patients with axial spondyloarthritis (axSpA) initiating tumor necrosis factor inhibitors (TNFi), interleukin‐17 inhibitors (IL‐17i), or JAK inhibitors (JAKi). Methods Using data from the Rheumatology Informatics System for Effectiveness (RISE) Registry (2003–2025), we assessed ...
Rachael Stovall, Cinthia Blat, Eric Roberts, Jean W. Liew, Katherine Wysham, Namrata Singh, Janna Friedly, Lianne S. Gensler, Gabriela Schmajuk, Jinoos Yazdany   +9 more
wiley   +1 more source

المدارس الأهلية والأجنبية ودورها في غرس القيم التربوية لدى طلاب المرحلة الابتدائية (الرياض نموذجا) (دراسة وصفية – تحليلية) [PDF]

Buḥūṯ
المستخلص:هدفت الدراسة إلى معرفة دور المدارس الأهلية والأجنبية في غرس القيم التربوية لدى طلاب المرحلة الابتدائية. واستخدم الباحث المنهج (الوصفي التحليلي) في دراسته، وقد احتوت الدراسة على (مقدمة وثلاثة فصول)، واحتوى كل فصل على مبحثين وثلاثة مطالب لكل مبحث.
سعد عبدالله, عاطف أحمد شاهين   +1 more
doaj   +1 more source