Results 131 to 140 of about 59,038 (377)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

ISTORICUL APARIŢIEI ŞI EVOLUŢIEI MĂSURILOR ALTERNATIVE PRIVAŢIUNII DE LIBERTATE ÎN REPUBLICA MOLDOVA

Studia Universitatis Moldaviae: Stiinte Sociale, 2007
La lutte contre l’infraction remonte aux époques historiques les plus anciennes. Au début, la peine était envisagée comme une nécessité impérative inspirant toujours la peur.
USM ADMIN
doaj  

Prática de privação de liberdade em adolescentes: um enfoque psicossociológico Practice of freedom privation in teenagers: a psychosocial approach

Psicologia em Estudo, 2011
O Estatuto da Criança e do Adolescente contém artigos reguladores da prática do ato infracional e dos procedimentos socioeducativos que conduzem o adolescente à reflexão sobre o ato infracional cometido e seu futuro retorno ao convívio sociofamiliar ...
Maria da Penha de Lima Coutinho, Ionara Dantas Estevam, Ludgleydson Fernandes de Araújo, Lidiane Silva Araújo   +3 more
doaj   +1 more source

Private Secure Coded Computation [PDF]

arXiv, 2019
We introduce a variation of coded computation that ensures data security and master's privacy against workers, which is referred to as private secure coded computation. In private secure coded computation, the master needs to compute a function of its own dataset and one of the datasets in a library exclusively shared by external workers.
arxiv  

Tolkien and the Deadly Sin of Greed [PDF]

, 2017
Tolkien’s genius as a writer and insight as a philosopher and theologian (of sorts) are reflected in his subtle yet impactful interweaving of the consequences of greed within the lives of the peoples of Middle-Earth.
Kieffer, Amanda A
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Condiciones de vida y fragmentación socio-espacial en el aglomerado Gran San Miguel de Tucumán (Noroeste Argentino) [PDF]

Estudios Socioterritoriales: Revista de Geografía, 2014
El noroeste de Argentina (NOA) es el territorio donde la pobreza alcanza las condiciones más críticas y la calidad de vida registra los estándares más bajos.
Paula Boldrini Peralta, Alejandra del Castillo, Matilde Malizia   +2 more
doaj  

Participação arriscada: manifestações e tumultos em regimes ditatoriais

Dados: Revista de Ciências Sociais, 2008
Dans cet article, on contrôle de façon empirique, tout en utilisant un large échantillon de pays, les différentes théories sur dissension et protestation au coeur des régimes autoritaires, où ces activités sont souvent traquées et forcément périlleuses ...
Abel Escribà-Folch
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

The microbiota and the host organism switch between cooperation and competition based on dietary iron levels

Gut Microbes
The microbiota significantly impacts digestive epithelium functionality, especially in nutrient processing. Given the importance of iron for both the host and the microbiota, we hypothesized that host-microbiota interactions fluctuate with dietary iron ...
Marie-Louise Noordine, Yohannes Seyoum, Aurélia Bruneau, Kaleab Baye, Thibaud Lefebvre, Claire Cherbuy, François Canonne-Hergaux, Gaël Nicolas, Christèle Humblot, Muriel Thomas   +9 more
doaj   +1 more source