Results 51 to 60 of about 51,689 (257)

The Good, the Bad, and the Ugly: Does Plato Make Room for Negative Forms in His Ontology? [PDF]

open access: yes, 2017
Plato seems to countenance both positive and negative Forms, that is to say, both good and bad ones. He may not say so outright, but he invokes both and rejects neither.
Alican, Necip Fikri
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Reminiscenses of Manichaeism in Augustine’s City of God

open access: yesHTS Teologiese Studies/Theological Studies, 2016
This article aims to analyse all the passages in Augustine’s City of God in which he either explicitly or implicitly makes mention of Manichaeism and its doctrines. It turns out that, even in his later years, Manichaean doctrines were at the forefront of
Johannes van Oort
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

On the omniscience of Aristotle\u2019s unmoved mover: a note on Metaphysics \u39b 4, 1070 b 34-35 [PDF]

open access: yes, 2018
This paper focuses on the final passage of Metaphysics \u39b 4, which contains the first explicit mention of the unmoved mover in book \u39b. The sentence is crucial for the problem of what, if anything, the Aristotelian god knows about the world.
Salis, RITA MARIA GAVINA
core  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Pursuing Pankalia: The Aesthetic Theodicy of St. Augustine [PDF]

open access: yes, 2016
This chapter summarizes Augustine’s often-neglected aesthetic theodicy that balances his metaphysical definitions of evil and human agency against the ultimately beautiful story Augustine sees God, as the author of all Creation, writing. First, Augustine’
Holdier, A. G.
core  

Against the Odds: Psychomotor Development of Children Under 2 years in a Sudanese Orphanage. [PDF]

open access: yes, 2011
Providing abandoned children the necessary medical and psychological care as possible after their institutionalization may minimize developmental delays. We describe psychomotor development in infants admitted to an orphanage in Khartoum, Sudan, assessed
Bakermans-Kranenburg   +21 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

A economia solidária diante das desigualdades

open access: yesDados: Revista de Ciências Sociais, 2007
Dans cet article, on discute les espoirs placés dans l'économie solidaire face aux inégalités, à partir de résultats empiriques trouvées dans des recherches sur des expériences modèles de ce genre d'économie.
Hans Benno Asseburg, Luiz Inácio Gaiger
doaj   +1 more source

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