Results 81 to 90 of about 17,189 (329)

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Pauvre de nous ! La pauvreté entre exclusion, privation et dépossession

MediAzioni
This article takes a multidisciplinary approach, highlighting the diversity of approaches to the phenomenon of poverty. A first review discusses the interest and limits of approaches to poverty based on the figure of the marginalized, with a focus on ...
Patrick Dieuaide
doaj   +1 more source

Private Coded Computation for Machine Learning [PDF]

arXiv, 2018
In a distributed computing system for the master-worker framework, an erasure code can mitigate the effects of slow workers, also called stragglers. The distributed computing system combined with coding is referred to as coded computation. We introduce a variation of coded computation that protects the master's privacy from the workers, which is ...
arxiv  

The relative impact of private research on scientific advancement [PDF]

arXiv, 2020
Literature about the scholarly impact of scientific research offers very few contributions on private sector research, and the comparison with public sector. In this work, we try to fill this gap examining the citation-based impact of Italian 2010-2017 publications distinguishing authorship by the private sector from the public sector.
arxiv  

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Male muscle strength response to two methodologies for 1RM testing

Revista Brasileira de Cineantropometria e Desempenho Humano, 2007
The aims of this study were to valuate and to compare the weight moved during the execution of the 1 RM test using two different methodologies: with and without visual privation. The sample was composed of twelve men with age 29 ± 7.9 years, weight 79.1±
Moises Marinho De Oliveira, Danilo Andrade Edmundo, André Gustavo De Paula Santos Matoso, Ângelo Testa Varallo, Alex Souto Maior, Valquiria Aparecida Minari   +5 more
doaj  

The association between sleep deprivation and arterial pressure variations: a systematic literature review

Sleep Medicine: X, 2022
Objectives: Arterial hypertension is a cardiovascular disease defined as a sustained high blood pressure, constituting an important risk factor for the development of heart diseases, such as coronary heart disease and heart failure.
Alécio Vinícius Sá Gomes e Farias, Mariana Peixoto de Lima Cavalcanti, Marcelo Alcântara de Passos Junior, Bruna del Vechio Koike   +3 more
doaj  

Le saint et son corps: une lutte constante

Al-Qantara : Revista de Estudios Arabes, 2000
Les corpus hagiographiques du Moyen Age offrent un catalogue impressionant de maladies car Dieu met les fidèles à l'épreuve en les accablant de maux spectaculaires, signes visibles qui marquent l'élection spirituelle.
Halima Ferhat
doaj   +1 more source

L'état d'esprit des individus en période de confinement

Moroccan Journal of Quantitative and Qualitative Research, 2021
L’Algérie étant confrontée à l’apparition du COVID-19, depuis le mois de février. Les autorités algériennes prennent comme première mesure le confinement dans différentes wilayas afin de réduire le risque de contamination.
Nadjat DJAMANE-SEGUENI, Mohammed Fayçal DJAMANE   +1 more
doaj   +1 more source