Results 81 to 90 of about 51,689 (257)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

ISTORICUL APARIŢIEI ŞI EVOLUŢIEI MĂSURILOR ALTERNATIVE PRIVAŢIUNII DE LIBERTATE ÎN REPUBLICA MOLDOVA

open access: yesStudia Universitatis Moldaviae: Stiinte Sociale, 2007
La lutte contre l’infraction remonte aux époques historiques les plus anciennes. Au début, la peine était envisagée comme une nécessité impérative inspirant toujours la peur.
USM ADMIN
doaj  

Condiciones de vida y fragmentación socio-espacial en el aglomerado Gran San Miguel de Tucumán (Noroeste Argentino) [PDF]

open access: yesEstudios Socioterritoriales: Revista de Geografía, 2014
El noroeste de Argentina (NOA) es el territorio donde la pobreza alcanza las condiciones más críticas y la calidad de vida registra los estándares más bajos.
Paula Boldrini Peralta   +2 more
doaj  

Prática de privação de liberdade em adolescentes: um enfoque psicossociológico Practice of freedom privation in teenagers: a psychosocial approach

open access: yesPsicologia em Estudo, 2011
O Estatuto da Criança e do Adolescente contém artigos reguladores da prática do ato infracional e dos procedimentos socioeducativos que conduzem o adolescente à reflexão sobre o ato infracional cometido e seu futuro retorno ao convívio sociofamiliar ...
Maria da Penha de Lima Coutinho   +3 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

Condiciones de vida y pobreza consistente

open access: yesRect@, 2009
RESUMEN Este trabajo examina la privación en las condiciones de vida en España lo que, unido a la información sobre pobreza monetaria, permite identificar a la población en situación de pobreza consistente.
García Luque, Olga   +2 more
doaj  

Participação arriscada: manifestações e tumultos em regimes ditatoriais

open access: yesDados: Revista de Ciências Sociais, 2008
Dans cet article, on contrôle de façon empirique, tout en utilisant un large échantillon de pays, les différentes théories sur dissension et protestation au coeur des régimes autoritaires, où ces activités sont souvent traquées et forcément périlleuses ...
Abel Escribà-Folch
doaj   +1 more source

Phenomenological models of inter-subjectivity: the position of Michel Henry [PDF]

open access: yes, 2016
In this paper, I would like to provide some of the elements necessary for a comprehension of Michel Henry’s position within the context of the phenomenological debate on inter-subjectivity.
Bancalari, Stefano
core  

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

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