Results 121 to 130 of about 958,828 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Positive Psychology & Sustainable Behavior: The Effect of Perceived Social Support on Individuals’ Pro-Environmental Behavior

SAGE Open
Both positive psychology and pro-environmental behavior are highly associated with individuals’ well-being. While previous studies have investigated the drivers of sustainable behavior, very few pieces have examined the influence of perceived social ...
Xiaotong Jin, Yong Zhu, Xiao Yang, Han Zhang   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Whatever people say I am, that's what I am: Social labeling as a social marketing tool. [PDF]

In this paper, we present a procedure to apply the social labeling technique as a social marketing tool. With four studies, we tested its potential for the promotion of pro-environmental consumer behavior.
Cornelissen, Gert, Dewitte, Siegfried, Warlop, Luk   +2 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

PRO-ENVIRONMENTAL BEHAVIORS IN TÜRKIYE: A SCALE DEVELOPMENT STUDY

Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi
The increase in the global temperature, wildfires, and droughts that occurred in the past decades have presented a preview of what would happen if people do not start taking action to protect the environment. Considering the importance of human actions to save the planet, we developed a culture-specific tool to measure pro-environmental behaviors in ...
Ece Ceren Akkaya, Erkin Sarı, Merve Nur Şahin, Yağmur Rumeli, Elif Darıcı, Gülden Sayılan   +5 more
openaire   +2 more sources

Pro-environmental behavior : On the interplay of intrinsic motivations and external conditions [PDF]

, 2017
A key issue for ecological economics concerns the processes whereby people engage in ecologically responsible behavior and contribute to environmental quality even when they involve a personal cost for a shared benefit.
Padilla, Emilio, Silvi, María Teresa
core  

Assessment of Environmental Consciousness among Patrons in Selected Academic and Public Libraries in Lagos Metropolis [PDF]

, 2020
The study examined environmental consciousness patterns among patrons in academic and public libraries. Using the survey method, data was collected from 383 patrons who were conveniently selected from six libraries in Lagos metropolis.
Alabi, Adefunke O.
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source