Results 81 to 90 of about 958,828 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Media Influence on Tourists’ Pro-Environmental Behavior: An Analysis of Environmental Cognitive Evaluation in the Context of Chinese Tourism

SAGE Open
This study examines how media use influences tourists’ pro-environmental behavior in China through environmental cognitive appraisal and a theoretical framework.
Ying Zhang, Hui-Ling Hu
doaj   +1 more source

Akankah Masyarakat Yang Bahagia Menjaga Lingkungannya? [PDF]

, 2017
Previous studies found that when individuals can demonstrate behaviors that contribute to nature preservation, it can be said that he has a high level of Subjective Well-being (SWB). It is because the ecological behavior is categorized as positive action
ARLINKASARI, F. (FITRI), CANINSTI, R. (RISELLIGIA), RADYANTI, P. U. (PUTRI)   +2 more
core  

Spanish version of the new ecological paradigm scale for children [PDF]

, 2013
The New Ecological Paradigm (NEP) scale has been extensively used to measure adults’ environmental attitudes. However, it has only recently been adapted for use with children.
Bethelmy Rincón, Lisbeth, Collado Salas, Silvia, Corraliza, José Antonio   +2 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Explaining energy conservation and environmental citizenship behaviors using the value-belief-norm framework

Despite decades of research, uncertainty remains about what motivates individuals to engage in pro-environmental behavior. The multifaceted and complex nature of energy conservation, like other forms of pro-environmental behavior, still poses a challenge
Kaplowitz, Michael D, Yeboah, Felix Kwame   +1 more
core   +1 more source

Is Pro-Environmental Consumption Utility-Maximizing? Evidence from Subjective Well-Being Data [PDF]

, 2010
This paper studies whether pro-environmental consumption choices are consistent with utility maximization and what role the consumption behavior of reference persons and one's own past behavior play in this context.
Kühling, Jan, Welsch, Heinz
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source