Results 141 to 150 of about 354,299 (286)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Neuropsychology of Cognitive Functions Related to Pro-Environmental Behavior

open access: yesPsikiyatride Güncel Yaklaşımlar
The daily habits and behaviors of modern society people harm the environment more than expected. It is well known that in order to protect the inherent values of the natural assets of the world we live in, and to sustain the mutual interaction of people ...
Serra Şandor
doaj   +1 more source

Pro-Environmental Behaviors and Well-Being in Adolescence: The Mediating Role of Place Attachment. [PDF]

open access: yesInt J Environ Res Public Health, 2023
Bartolo MG   +4 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

More “Nudging” for pro-environmental behavior

open access: yesInternational Journal of Behavior Studies in Organizations, 2020
The effects of global warming became aware for every one during the last years. Most of the scientists support the opinion that the partly rough changes in the climate and the pollution of the planet are closely related to the behavior of the peoples around the world.
openaire   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

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