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Pro-inflammatory Cytokines and Osteocytes
Current Osteoporosis Reports, 2019An elevated level of pro-inflammatory cytokines in inflammatory conditions causes bone loss and disrupts vital organ function. Osteocytes comprise > 95% of the cellular component in bone tissue, produce a range of cytokines and signaling molecules, and influence bone and other organ function.
Miao Zhou +2 more
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Pro-inflammatory cytokines in Alzheimer’s disease
Psychiatriki, 2016Alzheimer's disease (AD), the most common progressive neurodegenerative disorder in the elderly, is clinically characterized by progressive impairment of cognitive functions, including reduced critical capacity, weakness of decision-making and problem orientation, while in the more advanced stages it is accompanied by behavioral disorders and impaired ...
E C, Stamouli, A M, Politis
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Pro-inflammatory Cytokines in Animal and Human Gestation
Current Pharmaceutical Design, 2010The story of cytokines in pregnancy began about 30 years ago, approximately in concomitance with the understanding that cytokines are autocrine-paracrine regulators of physiological processes. Pro-inflammatory cytokines are predominant in the early and late events of gestation, e.g.
Ricci, Luana +5 more
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Pro‐inflammatory cytokines in patients with essential hypertension
European Journal of Clinical Investigation, 2001BackgroundIt has been suggested that abnormalities in the immune response play a role in the pathogenesis of essential hypertension (EH). The aim of this study was to assess circulating concentrations and ex vivo production of the pro‐inflammatory cytokines tumour necrosis factor‐α(TNF‐α) and interleukin‐1β (IL‐1β), and of the anti‐inflammatory ...
Peeters, A.C.T.M. +5 more
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Pro-Inflammatory Cytokine Response in Acute Infection
2003The invasion of human beings or other multi-cellular organisms by micro-organisms usually leads to inflammation. Depending on the virulence of the micro-organism, the size of the inoculum, and the quality of the host’s defence mechanisms, the inflammatory response will be confined to the local site or may extend and involve the entire body.
Alisjahbana, B. +2 more
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The paradox of pro-inflammatory cytokines in cancer
Cancer and Metastasis Reviews, 2006Cytokines such as IL-1 and TNF are primarily pro-inflammatory. The inflammation induced by these cytokines is reflected in the type of genes they induce. In the pathogenesis of carcinogenesis as well as tumor growth and spread, cytokines such as IL-1 and TNF induce chemokines that attract neutrophils.
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Pro-Inflammatory Cytokines in Elective Flap Surgery
Journal of Surgical Research, 2007Surgical trauma releases inflammatory mediators such as pro-inflammatory cytokines. In this prospective, controlled, randomized trial we investigated the release of pro-inflammatory cytokines and monocyte/macrophage activation in patients scheduled for breast reconstruction after mastectomy.
Annette, Schmidt +3 more
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Regulation of Multidrug Resistance by Pro-Inflammatory Cytokines
Current Cancer Drug Targets, 2006Various mechanisms have been implicated in the development of resistance of cancer cells to chemotherapy. Multidrug resistance (MDR) is a phenomenon in which cancer cells are resistant to the cytotoxic effects of various structurally and mechanistically unrelated chemotherapeutic agents.
Emmanuel A, Ho +1 more
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Pro-inflammatory cytokines and their effects in the dentate gyrus
2007The older notion of a central nervous system existing in essential isolation from the immune system has changed dramatically in recent years as the body of evidence relating to the interactions between these two systems has grown. Here we address the role of a particular subset of immune modulatory molecules, the pro-inflammatory cytokines, in ...
Mark, Pickering, John J, O'Connor
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Airway nociceptors activated by pro-inflammatory cytokines
Respiratory Physiology & Neurobiology, 2007The present studies evaluate whether the vagus nerves link the lungs' immune and neural systems by transmitting information through pulmonary nociceptors. Single unit activities from pulmonary nociceptors [C fiber receptors (CFRs) and high threshold Adelta fiber receptors (HTARs)] were recorded from the cervical vagus nerve in anesthetized, open-chest,
Jerry, Yu +4 more
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