Results 91 to 100 of about 434,486 (268)

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

A probabilistic position value [PDF]

In this article, we generalize the position value, defined by Meessen (1988) for the class of deterministic communication situations, to the class of generalized probabilistic communication situations (G´omez et al. (2008)).
Conrado Manuel, Enrique Gonzalez-Arangüena, Amandine Ghintran   +2 more
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Probabilistic Computational Trust

, 2009
We argue briefly for the role of computational trust in ubiquitous computing, and in particular for the need of a formal foundation for computational trust.
Krukow, Karl, Nielsen, Mogens, Sassone, Vladimiro   +2 more
core  

Empirical Risk Minimization for Probabilistic Grammars: Sample Complexity and Hardness of Learning

, 2012
Probabilistic grammars are generative statistical models that are useful for compositional and sequential structures. They are used ubiquitously in computational linguistics.
Noah A. Smith, Smith, N. A., Shay B. Cohen, Cohen, S. B.   +3 more
core   +1 more source

Seamless Short‐ to Mid‐Term Probabilistic Wind Power Forecasting

Wind Energy
This paper brings a new understanding to the relative importance of different uncertainty sources across forecast horizons up to 7 days ahead. It presents a method for probabilistic wind power forecasting that quantifies uncertainty from weather ...
Gabriel Dantas, Jethro Browell
doaj   +1 more source

Determination of Local Site-Specific Spectra Using Probabilistic Seismic Hazard Analysis for Bitlis Province, Turkey

Earth Sciences Research Journal, 2015
In this study, site-specific earthquake spectra for Bitlis province in Lake Van Basin has been obtained. It is noteworthy that, in probabilistic seismic hazard assessment, as a first stage data from geological studies and records from the instrumental ...
Ercan Işık, Mustafa Kutanis
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Probabilistic load flow in systems with high wind power penetration [PDF]

, 2008
This paper proposes a method for solving a probabilistic load flows that takes into account the uncertainties of wind generation, but also of load and conventional systems.
Usaola García, Julio, Usaola, Julio
core