Results 61 to 70 of about 21,014 (291)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Probabilistic Eigenvalue Shaping for Nonlinear Fourier Transform Transmission [PDF]

, 2018
We consider a nonlinear Fourier transform (NFT)-based transmission scheme, where data is embedded into the imaginary part of the nonlinear discrete spectrum. Inspired by probabilistic amplitude shaping, we propose a probabilistic eigenvalue shaping (PES)
Amat, Alexandre Graell i, Aref, Vahid, Buchberger, Andreas, Schmalen, Laurent   +3 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Ultra-Sparse Non-Binary LDPC Codes for Probabilistic Amplitude Shaping

, 2017
This work shows how non-binary low-density parity-check codes over GF($2^p$) can be combined with probabilistic amplitude shaping (PAS) (B\"ocherer, et al., 2015), which combines forward-error correction with non-uniform signaling for power-efficient ...
Böcherer, Georg, Liva, Gianluigi, Steiner, Fabian   +2 more
core   +1 more source

A Journey from Improper Gaussian Signaling to Asymmetric Signaling

, 2020
The deviation of continuous and discrete complex random variables from the traditional proper and symmetric assumption to a generalized improper and asymmetric characterization (accounting correlation between a random entity and its complex conjugate ...
Alouini, Mohamed-Slim, Amin, Osama, Javed, Sidrah, Shihada, Basem   +3 more
core   +1 more source

Joint Design of Probabilistic Constellation Shaping and Precoding for Multi-user VLC Systems [PDF]

Global Communications Conference
This paper proposes a joint design of probabilistic constellation shaping (PCS) and precoding to enhance the sum-rate performance of multi-user visible light communications (VLC) broadcast channels subject to signal amplitude constraint.
Thang K. Nguyen, Thanh V. Pham, Hoang D. Le, Chuyen T. Nguyen, Anh T. Pham   +4 more
semanticscholar   +1 more source

Evaluating the Impact of the Guard Band Width on the Benefits of Probabilistic Constellation Shaping in Future Flex-Grid over Multicore Fibre Optical Backbone Networks

International Conference on Transparent Optical Networks, 2023
Probabilistic constellation shaping (PCS) has emerged as an advanced modulation technique that provides a fine-grained software-defined trade-off between achievable spectral efficiency (SE) and transmission reach to deliver optimal channel capacity at ...
J. Perelló, J. Gené, Junho Cho, S. Spadaro   +3 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Deep Learning of Geometric Constellation Shaping including Fiber Nonlinearities [PDF]

, 2018
A new geometric shaping method is proposed, leveraging unsupervised machine learning to optimize the constellation design. The learned constellation mitigates nonlinear effects with gains up to 0.13 bit/4D when trained with a simplified fiber channel ...
Eriksson, Tobias A., Jones, Rasmus T., Yankov, Metodi P., Zibar, Darko   +3 more
core   +2 more sources