Results 51 to 60 of about 18,495 (249)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Underwater Network Time Synchronization Method Based on Probabilistic Graphical Models
Journal of Marine Science and EngineeringIn underwater clustering and benchmark networks, nodes need to reduce the rate and energy consumption of acoustic communication while ensuring synchronization accuracy.
Yujie Ouyang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
High-dimensional Data Publication Under Local Differential Privacy [PDF]
Jisuanji kexueWith the increasing availability of high-dimensional data collected from numerous users,preserving user privacy while utilizing high-dimensional data poses significant challenges.This paper focuses on the problem of high-dimensional data publication ...
CAI Mengnan, SHEN Guohua, HUANG Zhiqiu, YANG Yang
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An Introduction to Probabilistic Graphical Models
, 2002 In this chapter we will introduce two probabilistic graphical models -Bayesian networks and Gaussian networks- that will be used to carryout factorization of the probability distribution of the selected individuals in the Estimation of Distribution Algorithms based approaches.
openaire +2 more sources
Statistical inference with probabilistic graphical models
CoRR, 2014 Chapter of "Statistical Physics, Optimization, Inference, and Message-Passing Algorithms", Eds.: F. Krzakala, F. Ricci-Tersenghi, L. Zdeborova, R. Zecchina, E. W. Tramel, L. F. Cugliandolo (Oxford University Press, to appear)
Angélique Dremeau +3 more
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source