Results 41 to 50 of about 117,066,488 (245)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Probabilistic Linguistic Three-Way Group Consensus Framework Integrating Bayesian Best–Worst Method and Regret Theory for Age-Friendliness Evaluation of Aging Urban Residential Communities

Mathematics
Multi-criteria group decision making (MCGDM) under linguistic uncertainty remains a fundamental challenge in applied mathematics, where decision makers seldom assign crisp numerical evaluations and frequently exhibit heterogeneous risk attitudes shaped by behavioural factors.
Zhanyu Zhong, Chang Yang, Cong Chen, Fukang Zhao, Kaixing Tang   +4 more
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Proceedings of the 25th Conference on Formal Methods in Computer-Aided Design, FMCAD 2025 [PDF]

The Conference on Formal Methods in Computer-Aided Design (FMCAD) is an annual conference on the theory and applications of formal methods in hardware and system verification.
Formal Methods in Computer Aided Design
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

A Comparative Analysis of Empirical Copula and Quantile Regression Methods for Probabilistic Load Forecasting

This paper presents a detailed comparative analysis of two data-driven probabilistic forecasting methods - a density-based Empirical Copula (EC) and a non-parametric Quantile Regression (QR) - in the context of load forecasting for day-ahead market ...
Chevron, Max, De Falco, Pasquale, Perna, Sara, Austnes, Pal Forr, Gerini, Francesco, Di Fazio, Anna Rita, Paolone, Mario   +6 more
core   +1 more source

07391 Abstracts Collection – Probabilistic Methods in the Design and Analysis of Algorithms [PDF]

, 2007
From 23.09.2007 to 28.09.2007, the Dagstuhl Seminar 07391 "Probabilistic Methods in the Design and Analysis of Algorithms''was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl.
Teng, Shang-Hua, Upfal, Eli, Dietzfelbinger, Martin, Vöcking, Berthold   +3 more
core   +1 more source

A quantum probability theory-based method for heterogeneous multi-criteria group decision making with incomplete probabilistic linguistic preference relations considering the interference effect among decision makers

Journal of the Operational Research Society
Quantum probability theory (QPT) reveals that decision makers (DMs) can interfere with each other and thus affect the decision result. However, existing methods of heterogeneous multi-criteria group decision making (HMCGDM) seldom consider the interference effect among DMs.
Jia Yan, Jiu-Ying Dong, Shu-Ping Wan, Yu Gao 0034   +3 more
openaire   +2 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Probabilistic load flow in systems with high wind power penetration [PDF]

, 2008
This paper proposes a method for solving a probabilistic load flows that takes into account the uncertainties of wind generation, but also of load and conventional systems.
Usaola García, Julio, Usaola, Julio
core   +1 more source