Results 51 to 60 of about 205,855 (287)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Ensemble forecasting of major solar flares: methods for combining models

Journal of Space Weather and Space Climate, 2020
One essential component of operational space weather forecasting is the prediction of solar flares. With a multitude of flare forecasting methods now available online it is still unclear which of these methods performs best, and none are substantially ...
Guerra Jordan A., Murray Sophie A., Shaun Bloomfield D., Gallagher Peter T.   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

n-Tuplet Coincidence Point Theorems in Partially Ordered Probabilistic Metric Spaces

Journal of Function Spaces, 2018
In this paper, we investigate existence of n-tuplet coincidence point theorems in partially ordered probabilistic metric spaces. Also, we gave uniqueness of n-tuplet fixed point theorems in this space.
Arife Aysun Karaaslan, Vatan Karakaya
doaj   +1 more source

COVARIANT INTEGRAL QUANTIZATIONS AND THEIR APPLICATIONS TO QUANTUM COSMOLOGY

Acta Polytechnica, 2016
We present a general formalism for giving a measure space paired with a separable Hilbert space a quantum version based on a normalized positive operator-valued measure.
Jean-Pierre Gazeau
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Common fixed point theorem for noncompatible maps in probabilistic metric space [PDF]

Surveys in Mathematics and its Applications, 2013
In this paper, we prove a common fixed point theorem for noncompatible maps in probabilistic metric space using implicit relation. Our result does not require either the completeness of the space or continuity of the maps.
Suneel Kumar, Sunny Chauhan, B. D. Pant
doaj  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

New approaches for assessing the activities of operators of complex technical systems

Экспериментальная психология, 2019
Presented are new approaches for supporting the outcome grading for activities of operators of complex technical systems, which are based on comparisons of current exercises with the activity database patterns in both the wavelet ...
L.S. Kuravsky, G.A. Yuryev, V.I. Zlatomrezhev   +2 more
doaj   +1 more source