Results 51 to 60 of about 23,525 (295)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Minimax theorems in probabilistic metric spaces [PDF]
Bulletin of the Australian Mathematical Society, 1995 In this paper, new minimax theorems for mixed lower-upper semicontinuous functions in probabilistic metric spaces are given. As applications, we utilise these results to show the existence of solutions of abstract variational inequalities, implicit variational inequalities and saddle point problems, and the existence of coincidence points in ...
Cho, Y. J. +4 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
COVARIANT INTEGRAL QUANTIZATIONS AND THEIR APPLICATIONS TO QUANTUM COSMOLOGY
Acta Polytechnica, 2016 We present a general formalism for giving a measure space paired with a separable Hilbert space a quantum version based on a normalized positive operator-valued measure.
Jean-Pierre Gazeau
doaj +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
New approaches for assessing the activities of operators of complex technical systems
Экспериментальная психология, 2019 Presented are new approaches for supporting the outcome grading for activities of operators of complex technical systems, which are based on comparisons of current exercises with the activity database patterns in both the wavelet ...
L.S. Kuravsky +2 more
doaj +1 more source
Probabilistic Autoencoder Using Fisher Information
Entropy, 2021 Neural networks play a growing role in many scientific disciplines, including physics. Variational autoencoders (VAEs) are neural networks that are able to represent the essential information of a high dimensional data set in a low dimensional latent ...
Johannes Zacherl +2 more
doaj +1 more source
Probabilistic metric spaces and hysteresis systems [PDF]
Communications in Mathematical Physics, 1971 A phenomenological theory of simple hysteresis is constructed with the aid of certain concepts from the theory of probabilistic metric spaces. The predicted forms of the dependence of average energy loss per hysteresis cycle on the maximum excursion of the hysteresis coordinate agree well with experimental results.
Erber, T., Schweizer, B., Sklar, A.
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source