Results 51 to 60 of about 4,634,933 (288)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A note on φ-contractions in probabilistic and fuzzy metric spaces [PDF]

Fuzzy Sets and Systems, 2017
[EN] In a recent paper Fang (2015) [1], J.X. Fang generalized a crucial fixed point theorem for probabilistic phi-contractions on complete Menger spaces due to Jachymski (2010) [3]. In this note we show that actually Fang s theorem is an easy consequence of Jachymski s theorem. We also observe that the proof of a fixed point theorem for complete metric
Carmen Alegre, Salvador Romaguera
openaire   +3 more sources

Fixed Point Result in Probabilistic Metric Space [PDF]

, 2013
In this paper we prove common fixed point theorem for four mapping with weak compatibility in probabilistic metric space. Keywords: Menger space, Weak compatible mapping, Semi-compatible mapping, Weakly commuting mapping, common fixed point.
Mehta, Smriti, Singh, Ruchi, Singh, A D
core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Hyperconvexity and endpoints in T₀-quasi-metric spaces [PDF]

, 2013
Over the last decades much progress has been made in the investigation of hyperconvexity in metric spaces. Recently Kemajou and others have published an article concerning hyperconvexity in T₀-quasi-metric spaces.
Haihambo, Paulus
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Ensemble forecasting of major solar flares: methods for combining models

Journal of Space Weather and Space Climate, 2020
One essential component of operational space weather forecasting is the prediction of solar flares. With a multitude of flare forecasting methods now available online it is still unclear which of these methods performs best, and none are substantially ...
Guerra Jordan A., Murray Sophie A., Shaun Bloomfield D., Gallagher Peter T.   +3 more
doaj   +1 more source

COVARIANT INTEGRAL QUANTIZATIONS AND THEIR APPLICATIONS TO QUANTUM COSMOLOGY

Acta Polytechnica, 2016
We present a general formalism for giving a measure space paired with a separable Hilbert space a quantum version based on a normalized positive operator-valued measure.
Jean-Pierre Gazeau
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source