Results 81 to 90 of about 4,634,933 (288)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Integrating Lipschitz Extensions and Probabilistic Modelling for Metric Space Classification

open access: yesMathematics
Lipschitz-based classification provides a flexible framework for general metric spaces, naturally adapting to complex data structures without assuming linearity.
Roger Arnau   +2 more
doaj   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi   +17 more
wiley   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay   +13 more
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers   +19 more
wiley   +1 more source

Coupled Fixed Point Theory over Quantale-Valued Quasi-Metric Spaces (QVQMS) with Applications in Generalized Metric Structures

open access: yesAxioms
In this study, we establish several coupled fixed point results in quantale-valued quasi-metric spaces (QVQMSs), which constitutes a generalization of metric and probabilistic metric spaces. The obtained results will be illustrated with concrete examples.
Irem Eroğlu
doaj   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie   +8 more
wiley   +1 more source

A Fully Abstract Metric-Space Denotational Semantics for Reactive Probabilistic Processes

open access: yes, 1998
Metric-Space Denotational Semantics for Reactive Probabilistic Processes M.Z. Kwiatkowska and G.J. Norman School of Computer Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK Abstract We consider the calculus of Communicating ...
G. J. Norman   +3 more
core   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

On Weak Probabilistic φ-Contractions in Menger Probabilistic Metric Spaces

open access: yesAxioms
Two new concepts are introduced in this paper: ZH-set and weak probabilistic φ-contraction. Firstly, a fixed-point theorem for weak probabilistic φ-contraction is given in Menger probabilistic metric spaces, which generalizes and unifies several results in the existing literature. Then, a best proximity point theorem is obtained.
Dingwei Zheng, Qingming He
openaire   +1 more source

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