Results 41 to 50 of about 389,689 (283)

Statistical analysis of uniaxial tensile and fatigue data of Ti-685 alloy at different temperatures

Forces in Mechanics, 2021
The probabilistic modelling on uniaxial tensile properties and fatigue life data is required for the safe gas turbine design. The probabilistic model will help the designer to calculate the risk factor at the applied load level and choose the proper ...
Surajit Kumar Paul, Anuradha Nayak Majila, D Chandru Fernando   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Interval reservoir computing: theory and case studies

Frontiers in Energy Research
The time series data in many applications, for example, wind power and vehicle trajectory, show significant uncertainty. Using a single prediction value of wind power as feedback information for wind turbine control or unit commitment is not enough since
Lan-Da Gao, Lan-Da Gao, Zhen-Hua Li, Zhen-Hua Li, Meng-Yi Wu, Meng-Yi Wu, Qing-Lan Fan, Qing-Lan Fan, Ling Xu, Ling Xu, Zhuo-Min Zhang, Zhuo-Min Zhang, Yi-Peng Zhang, Yi-Peng Zhang, Yan-Yue Liu, Yan-Yue Liu   +15 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Leveraging sanitized data for probabilistic electricity market prediction: a Singapore case study

Frontiers in Energy Research, 2023
In deregulated electricity markets, predicting price and load is a common practice. However, market participants and shareholders often seek deeper insights into other system statuses associated with price prediction, such as power flow and market share ...
Ning Zhou Xu, Xiang Gao, Songjian Chai, Ming Niu, Jia Xin Yang   +4 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Generative probabilistic prediction of precipitation induced landslide deformation with variational autoencoder and gated recurrent unit

Frontiers in Earth Science
Landslides, prevalent in mountainous areas, are typically triggered by tectonic movements, climatic changes, and human activities. They pose catastrophic risks, especially when occurring near settlements and infrastructure.
Wencheng Cai, Fuan Lan, Xianhao Huang, Junfeng Hao, Weifeng Xia, Ran Tang, Peng Feng, Huajin Li   +7 more
doaj   +1 more source

Probabilistic Prediction of Energy Demand and Driving Range for Electric Vehicles With Federated Learning

IEEE Open Journal of Vehicular Technology, 2021
Today's drivers of battery electric vehicles must deal with limited driving range in a sparse charging infrastructure. An accurate prediction of energy demand and driving range is therefore important and enables reliable routing and charge ...
Adam Thor Thorgeirsson, Stefan Scheubner, Sebastian Funfgeld, Frank Gauterin   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source