Results 241 to 250 of about 410,504 (298)

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Promoting structural sustainable design through the influence of quality control assessments. [PDF]

Sci Rep
Lux T, Feiri T, Schulze-Ardey JP, Hegger J, Claßen M, Ricker M.   +5 more
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

The Role of Reinforcement Learning in Pragmatic Reasoning Tasks: Modeling and Validating the Sources of Individual Differences. [PDF]

Open Mind (Camb)
Duff J, Mayn A, Demberg V.
europepmc   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Enhancing grain harvester fatigue reliability to support sustainable agriculture: A review of research status and prospects. [PDF]

Sci Prog
Tang Z, Wang H, Tian L, Lao L, Sun H.
europepmc   +1 more source

Allostery between Distant Structural Regions Dictates Selectivity in GPCR:G Protein Coupling. [PDF]

Biochemistry
Mukhaleva E, Sánchez Rivas EJ, Branciamore S, Rodin AS, Sivaramakrishnan S, Vaidehi N.   +5 more
europepmc   +1 more source

Heavy Metal-Induced Variability in Leaf Nutrient Uptake and Photosynthetic Traits of Avocado (Persea americana) in Mediterranean Soils: A Multivariate and Probabilistic Modeling of Soil-to-Plant Transfer Risks. [PDF]

Plants (Basel)
Sanad H, Moussadek R, Zouahri A, Oueld Lhaj M, Dakak H, Manhou K, Mouhir L.   +6 more
europepmc   +1 more source

Spatiotemporal imbalance of regional water shortage risk based on copulas and concentration index. [PDF]

Sci Rep
Qian T, Zhou D, Yuan Z, Li X, Xi W, Gu S, Chen J, Li X, Zhang Z, Guo Z.   +9 more
europepmc   +1 more source

Learning data-efficient coarse-grained molecular dynamics from forces and noise. [PDF]

Nat Commun
Durumeric AEP, Chen Y, Pasos-Trejo AS, Noé F, Clementi C.   +4 more
europepmc   +1 more source