Results 91 to 100 of about 2,314,269 (376)

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Nonparametric Forecasting of Multivariate Probability Density Functions [PDF]

SSRN Electronic Journal, 2018
The study of dependence between random variables is the core of theoretical and applied statistics. Static and dynamic copula models are useful for describing the dependence structure, which is fully encrypted in the copula probability density function. However, these models are not always able to describe the temporal change of the dependence patterns,
Dominque Guégan, Matteo Iacopini
openaire   +4 more sources

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Mean velocity and suspended sediment concentration profile model of turbulent shear flow with probability density function

Earth Sciences Research Journal, 2017
This work purposes a general mean velocity and a suspended sediment concentration (SSC) model to express distribution at every point of the cross section of turbulent shear flow by using a probability density function method.
Guanglin Wu, Liangsheng Zhu, Fangcheng Li   +2 more
doaj   +1 more source

Turbulence without pressure in d dimensions

, 1999
The randomly driven Navier-Stokes equation without pressure in d-dimensional space is considered as a model of strong turbulence in a compressible fluid. We derive a closed equation for the velocity-gradient probability density function.
A. Chekhlov, A. Polyakov, E. Balkovsky, E. Ivashkevich, J. Zinn-Justin, J.-P. Bouchaud, J.-P. Bouchaud, M. L. Mehta, S. A. Boldyrev, S. Boldyrev, S. Boldyrev, T. Gotoh, T. Gotoh, V. Gurarie, V. Yakhot, V. Yakhot, W. E   +16 more
core   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Estimate the probability density function of maximum temperature for the Middle East

Przegląd Naukowy Inżynieria i Kształtowanie Środowiska, 2020
Pollution is one reasons for increase temperature which leads to increase the heat waves which have large socioeconomic and healthy impacts on Middle East.
Iqbal K. Al-Ataby, Amani I. Al-Tmimi
doaj   +1 more source

Analysis of chaotic motion and its shape dependence in a generalized piecewise linear map

, 2001
We analyse the chaotic motion and its shape dependence in a piecewise linear map using Fujisaka's characteristic function method. The map is a generalization of the one introduced by R. Artuso.
B.A. Huberman, B.V. Chirikov, Chia-Chu Chen, E. Ben-Jacob, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. Fujisaka, H. Mori, H. Shibata, H.C. Tseng, H.G. Schuster, M. Cirillo, M. Inoue, M. Sabir, M. Schell, R. Artuso, R. Artuso, R.W. Leven, S. Grossmann, S. Rajagopalan, T. Geisel, T. Geisel   +24 more
core   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source