Results 41 to 50 of about 40,312 (249)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Track-Before-Detect Algorithm Based on Improved Auxiliary Particle PHD Filter under Clutter Background

Leida xuebao, 2019
Under the clutter background condition, the existing particle filter pre-detection tracking algorithm based on Probability Hypothesis Density (PHD) filtering is not accurate enough to estimate the number of targets in dense multi-objectives.
PEI Jiazheng, HUANG Yong, DONG Yunlong, HE You, CHEN Xiaolong   +4 more
doaj   +1 more source

A mixed GM/SMC implementation of the probability hypothesis density filter [PDF]

2012 11th International Conference on Information Science, Signal Processing and their Applications (ISSPA), 2012
The Probability Hypothesis Density (PHD) filter is a recent solution for tracking an unknown number of targets in a multi-object environment. The PHD filter cannot be computed exactly, but popular implementations include Gaussian Mixture (GM) and Sequential Monte Carlo (SMC) based algorithms.
Yohan Petetin, François Desbouvries
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Robust Student’s t Mixture Probability Hypothesis Density Filter for Multi-Target Tracking With Heavy-Tailed Noises

IEEE Access, 2018
In order to improve filtering accuracy and restrain the degradation of filtering performance caused by the heavy-tailed process and measurement noises in multi-target tracking, this paper proposes a robust Student's t mixture probability hypothesis ...
Zhuowei Liu, Shuxin Chen, Hao Wu, Kun Chen   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Variational Bayesian cardinalized probability hypothesis density filter for robust underwater multi-target direction-of-arrival tracking with uncertain measurement noise

Frontiers in Physics, 2023
The direction-of-arrival (DOA) tracking of underwater targets is an important research topic in sonar signal processing. Considering that the underwater DOA tracking is a typical multi-target problem under unknown underwater environment with missing ...
Boxuan Zhang, Boxuan Zhang, Xianghao Hou, Xianghao Hou, Yixin Yang, Yixin Yang, Jianbo Zhou, Jianbo Zhou, Shengli Xu, Shengli Xu   +9 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Refined PHD Filter for Multi-Target Tracking under Low Detection Probability

Sensors, 2019
Radar target detection probability will decrease as the target echo signal-to-noise ratio (SNR) decreases, which has an adverse influence on the result of multi-target tracking.
Sen Wang, Qinglong Bao, Zengping Chen
doaj   +1 more source

Active Sonar Target Tracking Based on the GM-CPHD Filter Algorithm [PDF]

Xibei Gongye Daxue Xuebao, 2018
The estimation of underwater multi-target state has always been the difficult problem of active sonar target tracking.In order to get the variable number of target and their state, the random finite set theory is applied to multi-target tracking system ...

doaj   +1 more source