Results 91 to 100 of about 225,906 (328)
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik +13 more
wiley +1 more source
Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology
Frontiers in Bioengineering and Biotechnology, 2020 Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar +2 more
doaj +1 more source
Modelling for research on chemical control of mammals in New Zealand [PDF]
, 1974 Development of predictive formulae or qualitative statements about the probable outcome of control campaigns entails knowledge of bait quality and distribution, behaviour, vagaries of weather at the time of the control campaign, and other factors which ...
Batcheler, C. L., Bell, J.
core +1 more source
Closed timelike curves via post-selection: theory and experimental demonstration
, 2010 Closed timelike curves (CTCs) are trajectories in spacetime that effectively travel backwards in time: a test particle following a CTC can in principle interact with its former self in the past. CTCs appear in many solutions of Einstein's field equations
Aephraim M. Steinberg +12 more
core +1 more source
Immune Predictors of Radiotherapy Outcomes in Cervical Cancer
Advanced Science, EarlyView.This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang +8 more
wiley +1 more source
Developing Artificial Intelligence Agents for a Turn-Based Imperfect Information Game [PDF]
, 2019 Artificial intelligence (AI) is often employed to play games, whether to entertain human opponents, devise and test strategies, or obtain other analytical data. Games with hidden information require specific approaches by the player.
Perez Cutright, Wilfrido
core +1 more source
Advanced Science, EarlyView.This study finds that CD8⁺ TSCM cells exhibit superior self‐renewal, differentiation, and antiviral activity. Transcriptome and epigenome analyses highlight MAPK cascade regulation in TSCM cells. In vivo, virus‐specific TSCM cells show enhanced persistence and tumor protection.
Xun‐Hong Cao +13 more
wiley +1 more source
Weed Search and Control: Theory and Application [PDF]
The detectability of invasive organisms influences the costs and benefits of alternative control strategies, and the feasibility of eradicating an infestation.
Cacho, Oscar J. +3 more
core +1 more source
The toll of the automobile [PDF]
, 2003 Animal-vehicle collisions are a common phenomenon worldwide, causing injury or death to millions of animals and hundreds of human passengers each year. Collision numbers can be significant to species conservation, wildlife management, traffic safety, as ...
Seiler, Andreas
core
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source