Results 71 to 80 of about 225,906 (328)

Effects of X-ray irradiation on human spermatogenesis [PDF]

, 1972
Direct cell kill and inhibition of mitosis have been suggested as mechanisms to explain the occurrence of absolute sterility following the irradiation of the testes.
Paulsen, C. A., Thorslund, T. W.
core   +1 more source

Bayesian inference for stochastic differential equation mixed effects models of a tumor xenography study

, 2019
We consider Bayesian inference for stochastic differential equation mixed effects models (SDEMEMs) exemplifying tumor response to treatment and regrowth in mice. We produce an extensive study on how a SDEMEM can be fitted using both exact inference based
Forman, Julie Lyng, Picchini, Umberto
core   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Ferritin‐Doped Nanoparticles Triggered Tumor‐Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation

Advanced Healthcare Materials, EarlyView.
Ferritin‐doped hybrid nanoparticles triggered accurate tumor‐specific hemorrhage for enhanced in situ photothermal therapy and evoked anti‐tumor immunity. Notably, HFn/GA‐Fe specifically induced tumor hemorrhage 12 h after intravenous injection, resulting in visible color darkening. Through photoacoustic imaging, tumor vessels could be clearly observed
Haidong Zha, Xiao Liang, Long Xi, Jiamao Chen, Wenzhao Zhong, Zhen Yuan, Meng Xu, Ying Zheng   +7 more
wiley   +1 more source

Determination of rainfall thresholds for shallow landslides by a probabilistic and empirical method [PDF]

Natural Hazards and Earth System Sciences, 2015
Rainfall-induced landslides not only cause property loss, but also kill and injure large numbers of people every year in mountainous areas in China. These losses and casualties may be avoided to some extent with rainfall threshold values used in an early
J. Huang, N. P. Ju, Y. J. Liao, D. D. Liu   +3 more
doaj   +1 more source

Coagulation reaction in low dimensions: Revisiting subdiffusive A+A reactions in one dimension

, 2009
We present a theory for the coagulation reaction A+A -> A for particles moving subdiffusively in one dimension. Our theory is tested against numerical simulations of the concentration of $A$ particles as a function of time (``anomalous kinetics'') and of
A. Blumen, B. H. Hughes, D. ben-Avraham, E. Kotomin, J. J. Ruiz-Lorenzo, Katja Lindenberg, S. B. Yuste, S. B. Yuste   +7 more
core   +1 more source

PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells

Advanced Materials, EarlyView.
Detecting proteins secreted by a single cell while retaining its viability remains challenging. A particles‐in‐particle (PiPs) system made by co‐encapsulating barcoded microparticles (BMPs) with a single cell inside an alginate hydrogel particle is introduced.
Félix Lussier, Byeong‐Ui Moon, Mojra Janta‐Polczynski, Yonatan Morocz, Fabian Svahn, Molly Shen, Ljuboje Lukic, Lidija Malic, Teodor Veres, Andy Ng, David Juncker   +10 more
wiley   +1 more source

Mapping single‐cell responses to population‐level dynamics during antibiotic treatment

Molecular Systems Biology, 2023
Treatment of sensitive bacteria with beta‐lactam antibiotics often leads to two salient population‐level features: a transient increase in total population biomass before a subsequent decline, and a linear correlation between growth and killing rates ...
Kyeri Kim, Teng Wang, Helena R Ma, Emrah Şimşek, Boyan Li, Virgile Andreani, Lingchong You   +6 more
doaj   +1 more source

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

Multimodal Actuation and Environment Adaptive Strategies of Bio‐Inspired Micro/Nanorobots in Precision Medicine

Advanced Robotics Research, EarlyView.
An introduction for multidrive and environment‐adaptive micro/nanorobotics: design and fabrication strategies, intelligent actuation, and their applications. Various intelligent actuation approaches—magnetic, acoustic, optical, chemical, and biological—can be synergistically designed to enhance flexibility and adaptive behavior for precision medicine ...
Aiqing Ma, Han Gong, Jiacheng Ouyang, Liqi Chen, Tianfang Kang, Yiran He, Guojun Huang, Sidi Zheng, Ting Yin, Hong Pan, Lintao Cai   +10 more
wiley   +1 more source