Results 81 to 90 of about 225,906 (328)
Informatics in Medicine Unlocked, 2019 Background: Currently, tumor control probability (TCP) can be determined through experiments and observations, which enable deriving its values and construction of phenomenological and mechanistic TCP models.
Terman Frometa-Castillo +2 more
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Stochastic Processes and their Applications, 1993 Supercritical linear birth-and-death processes are considered under the influence of disasters that arrive as a renewal process independent of the population size. The killing probability in a disaster is a function of time from the last disaster. A necessary and sufficient condition for almost sure extinction is derived.
Peng, NanFu +3 more
openaire +1 more source
Advanced Science, EarlyView.This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen +31 more
wiley +1 more source
The Determinants of Punishment: Deterrence, Incapacitation and Vengeance [PDF]
Does the economic model of optimal punishment explain the variation in the sentencing of murderers? As the model predicts, we find that murderers with a high expected probability of recidivism receive longer sentences.
Bruce Sacerdote, Edward L. Glaeser
core
Advanced Science, EarlyView.PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li +17 more
wiley +1 more source
Influence of maneuverability on helicopter combat effectiveness [PDF]
A computational procedure employing a stochastic learning method in conjunction with dynamic simulation of helicopter flight and weapon system operation was used to derive helicopter maneuvering strategies. The derived strategies maximize either survival
Falco, M., Smith, R.
core +1 more source
Advanced Science, EarlyView.Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo +12 more
wiley +1 more source
在以农业为主的景观中哺乳动物对易地放归的野生火鸡捕食的空间分布预测
Wildlife LettersTranslocating prey into unfamiliar environments may alter predator‐prey interactions on space utilization, making prey more vulnerable to predation. We predicted that the greater the edge density of cropland and developed land, the higher the probability
Guiming Wang +2 more
doaj +1 more source
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
Advanced Science, EarlyView.Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim +11 more
wiley +1 more source
Technical Note—Probability of Kill and Expected Destroyed Value if the Underlying Distributions Are Rotationally Symmetric [PDF]
Operations Research, 1976 We derive formulas for the probability of killing a point target and for the expected destroyed value of an area target when the value density function of the area target, the damage function, and the distribution of the center of damage function around the target center are rotationally symmetric. The result generalizes several well-known formulas.
openaire +1 more source