Results 241 to 250 of about 229,681 (276)

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Decoding the Structural Complexity of Viral RNAs with SHAPE to Guide Antiviral Therapeutics. [PDF]

Viruses
Broglia L, Canale C, Vandelli A, Tartaglia GG, Delli Ponti R.   +4 more
europepmc   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Evolving Redo Frame-Preserving Leaflet Resection: From Transcatheter to Surgical Aortic Valves. [PDF]

Ann Thorac Surg Short Rep
Solomon BJ, Sarantopoulos A, Howard T, Cubeddu RJ, Caranasos T.   +4 more
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Oral microbiome perturbations link periodontal health to cognitive ageing in a large community cohort. [PDF]

EBioMedicine
Li F, Liang X, Li J, Cui M, Ho TE, Li J, Yuan Z, Meng W, Man Lo EC, Fan M, Zhang Z, Jin L, Chen X, Lu H, Jiang Y.   +14 more
europepmc   +1 more source

What students ask matters: Static and longitudinal questioning patterns in student-LLM dialogue and self-reported cognitive engagement. [PDF]

PLoS One
Qu J, Dai L, Yin M.
europepmc   +1 more source

Iterative Multidisciplinary Development and Evaluation of a Patient-Facing Social Determinants of Health Chatbot Using Synthetic Data Simulation: Mixed Methods Study. [PDF]

JMIR Form Res
Maw AM, Lupi A, Johnson-Koenke R, Coats H, Zhou L, Li B, Mitchell J, Kotz A, Plasek J, Goss F.   +9 more
europepmc   +1 more source

Deep learning for RNA secondary structure determination: gauging generalizability and broadening the scope of traditional methods. [PDF]

RNA
Szikszai M, Wang TY, Krueger R, Mathews DH, Ward M, Aviran S.   +5 more
europepmc   +1 more source

Molecular cytokine-dependent mechanisms of periodontitis pathogenesis and the potential for pharmacological IL-1 modulation in disease treatment. [PDF]

Front Dent Med
Belenichev I, Popazova O, Dmytriieva O, Chertov S, Bukhtiyarova N, Ryzhenko V, Oliynyk S, Lee S, Yi KH.   +8 more
europepmc   +1 more source