Results 61 to 70 of about 13,927,470 (379)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

ANALISIS STRATEGI MENYEDERHANAKAN MASALAH SERUPA DAN SUDUT PANDANG LAIN PADA PERMASALAHAN NON RUTIN PENJUMLAHAN FUNGSI

open access: yesAksioma: Jurnal Program Studi Pendidikan Matematika, 2017
The problem of Addition Operation of Functions often emerges in Junior National Science and Math Olympiads at the regional level, provincial level, and national level.
Kartika Maharani Dwi Astuti   +1 more
doaj   +1 more source

Efektivitas Problem Solving Dalam Meningkatkan Kemampuan Memfokuskan Pertanyaan Pada Larutan Elektrolit Non-elektrolit [PDF]

open access: yes, 2015
This research aimed to describe the effectiveness of problem solving in increasing question focus ability in electrolyte-nonelectrolyte solution. The population this research was 440 students from all the MIA of the 10th grade in SMA Negeri 1 Natar for ...
Rudibyani, R. B. (Ratu)   +2 more
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Solving the missing heritability problem

open access: yesPLoS Genetics, 2019
The problem of missing heritability, that is to say the gap between heritability estimates from genotype data and heritability estimates from twin data, has been a source of debate for about a decade [1].
Alexander I. Young
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Pembelajaran Problem Solving Untuk Meningkatkan Keterampilan Inferensi Dan Mengkomunikasikan Materi Larutan Penyangga [PDF]

open access: yes, 2015
The research which use pre-experiment method had been done in SMAN 1 Seputih Raman with the purpose to describe practicality, effectiveness, and effect size of problem solving learning model in order to improve the inference and communicate skills on ...
Efkar, T. (Tasviri)   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Secondary School Teachers’ Perceptions about Their Problem Solving Abilities [PDF]

open access: yesİnönü Üniversitesi Eğitim Fakültesi Dergisi, 2008
The purpose of the study is to determine the perceptions of high school teachers abouttheir level of problem solving skills and to find out whether their perceptions differaccording to gender, seniority, branch, marital status, how many children they ...
Hasan DEMİRTAŞ, Burhanettin DÖNMEZ
doaj  

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