Results 61 to 70 of about 16,498,200 (273)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
When is a problem a research problem? [PDF]
, 1992 Various definitions of and approaches to research and research problems are explored with numerous examples given. Guiding criteria for applied research are also discussed, along with potential pitfalls, the role of intuition in the process, and the ...
Cronin, Blaise
core
, 2020 Scunthorpe is an industrial town in North Lincolnshire, England, with a population of about 80,000.
Francis, Darryl
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Education Sciences, 2019 Problem-oriented pedagogies have emerged as strategic way for universities to respond to an international higher education agenda that increasingly prioritises innovative, student-centred learning, and the cultivation of both civic and employability ...
Renae Acton
doaj +1 more source
Possibilities of geographic information system in solution making of the Sjenica's commune development [PDF]
Glasnik Srpskog Geografskog Društva, 2005 The paper describes reality method sand geographical information systems (GIS- technologies) in integration GIS system. Sjenica is a specific area of the our state and therefore must notes of all elements and factors in environmental.
Šabić Dejan, Milanović Miško
doaj +1 more source
The Effect of Problem Based Learning Model on Critical Thinking Skills in the Context of Chemical Reaction Rate [PDF]
, 2019 The previous research result showed that the learning model based on the investigation could increase the students' critical thinking skills. The aim of this research was to measure the effectiveness of the using of problem-based learning model to ...
Dakabesi, D. -. (Daud) +1 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Formation features of vocabulary units with a color designation component in the Yukagir language
Развитие образования, 2018 The article reveals the formation features of vocabulary units with a color designation component in the Yukagir language. The result of the study is the conclusion that the word formation of color terms in the dialects of the Yukagir language is ...
Margarita P. Lukina
doaj +1 more source
Re-Thinking the “Problem” in Inquiry-Based Pedagogies through Exemplarity and World-Oriented
Education Sciences, 2019 This paper conducts a theoretical exploration of the inquiry-problem in problem-oriented pedagogies. Specifically, the article draws on a critical reflection of the addition of a global and internationalisation dimension to the problem-oriented project ...
Simon Warren
doaj +1 more source