Results 61 to 70 of about 16,713,882 (274)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The stochastic matching problem [PDF]
, 2011 The matching problem plays a basic role in combinatorial optimization and in statistical mechanics. In its stochastic variants, optimization decisions have to be taken given only some probabilistic information about the instance.
A. Braunstein +12 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The interdisciplinary problem: an analysis
Analiza i Egzystencja, 2022 The purpose of this paper is to analyze the concept of the interdisciplinary problem using the categories of the logic of questions. The problem is seen in a logical and epistemic sense: the problem is a meaning of the question, and the question is a ...
Monika Walczak
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
A Relationship Between Problem Solving Ability and Students' Mathematical Thinking [PDF]
, 2017 This research have a purpose to know is there an influence of problem solving abilty to students mathematical thinking, and to know how strong problem solving ability affect students mathematical thinking.
Delima, N. (Nita)
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Education Sciences, 2019 Problem-oriented pedagogies have emerged as strategic way for universities to respond to an international higher education agenda that increasingly prioritises innovative, student-centred learning, and the cultivation of both civic and employability ...
Renae Acton
doaj +1 more source
When is a problem a research problem? [PDF]
, 1992 Various definitions of and approaches to research and research problems are explored with numerous examples given. Guiding criteria for applied research are also discussed, along with potential pitfalls, the role of intuition in the process, and the ...
Cronin, Blaise
core
, 2018 An important endeavor in computer science is to understand the expressive power of logical formalisms over discrete structures, such as words. Naturally, "understanding" is not a mathematical notion.
Place, Thomas, Zeitoun, Marc
core +3 more sources