Results 31 to 40 of about 599,088 (308)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Kemampuan Literasi Matematis Siswa Ditinjau dari Kemampuan Pemecahan Masalah Siswa SMP di Pontianak [PDF]

, 2016
This research aims to describe student's mathmatical literacy ability in terms of problem solving skill in Junior High School Pontianak. This research used descriptive method with case study research design.
Hartoyo, A. (Agung), Sirait, M. A. (Monika), Suratman, D. (Dede)   +2 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

THE PROFILE OF STUDENTS’ PROBLEM-SOLVING SKILLS TOWARD ENVIRONMENTAL POLLUTION TOPIC

Assimilation, 2023
Problem-solving is an essential skill that must be possessed by students, especially in learning biology. The purpose of this research is to determine the profile of students’ problem-solving skills in Senior High School 10 Palembang on environmental ...
Kurnia Utami, Hertien Koosbandiah Surtikanti, Diana Rochintaniawati   +2 more
doaj   +1 more source

Kemampuan Pemecahan Masalah Siswa dengan Penerapan Modeling Instruction pada Konsep Listrik Dinamis [PDF]

, 2015
This research aims to describe the problem solving skill of student in class X-7 SMA Negeri 5 Pekanbaru with the implementation of Modeling Instruction in lesson dynamic electric.
Azhar, A. (Azhar), Irianti, M. I. (Mitri), Wahyuni, S. W. (Sry)   +2 more
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Correlation Between Emotional Intelligence and Problem Solving Skill of Health Students of Faculty of Medicine Universitas Hasanuddin

Indonesian Contemporary Nursing Journal, 2018
Background: High demands in all conditions require proffesional health workers. In dealing with patients, health workers need high emotional intelligence and problem solving skills that are qualified to deal with various problems.
Hasnah Hasnah, Desy Ana Hendra, Hapsah Hapsah   +2 more
doaj   +1 more source

The overview of problem solving skill through online social networking platform [PDF]

, 2015
Problem-solving skill is one of the 21st century skills needed by students to be competitive in the future working world. However, international assessment results have shown Malaysian students are still weak in problem solving and many graduates face ...
Abdullah, Zaleha, Aris, Baharuddin, Jamari, Diyana, Mohamed, Hasnah, Mohd. Zaid, Norasykin   +4 more
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source