Results 61 to 70 of about 53,531 (301)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Prevalence of Problematic Internet Use and Internet Usage Pattern among Adolescents

open access: yesIndian Journal of Psychiatric Nursing, 2020
Background: There has been a rapid rise in the use and ease of access to the Internet worldwide, including South-East Asian countries like India. Problematic Internet use (PIU) has become a global phenomenon that causes a serious problem to the affected ...
Preeti Mathew, K. Raman
doaj   +1 more source

Differences between problematic internet and smartphone use and their psychological risk factors in boys and girls: a network analysis

open access: yesChild and Adolescent Psychiatry and Mental Health, 2023
Background Problematic internet and smartphone use are significant health challenges for contemporary adolescents. However, their mutual relationship is unclear because studies investigating these phenomena are scarce.
Dmitri Rozgonjuk   +5 more
doaj   +1 more source

PSYCHOLOGICAL FACTORS RELATED TO PROBLEMATIC INTERNET AND SMARTPHONE USE [PDF]

open access: yesNesne Psikoloji Dergisi, 2020
In today’s world, Internet and smartphones have become an essential part of our lives. Besides their advantages, there are also some drawbacks regarding their usage.
Başak Türküler AKA   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Problematic Internet Use: A Longitudinal Study Evaluating Prevalence and Predictors

open access: yesThe Journal of Pediatrics: X, 2019
Objective: To assess the prevalence over time and predictors of problematic internet use using the Problematic and Risky Internet Use Screening Scale (PRIUSS). We also identified an intermediate-risk PRIUSS score.
Megan A. Moreno, MD, MSEd, MPH   +4 more
doaj   +1 more source

eHealth Intervention for Problematic Internet Use (PIU) [PDF]

open access: yesCurrent Psychiatry Reports, 2016
Excessive use of the Internet is considered a problematic behaviour by clinicians and researchers. Cognitive behaviour therapy (CBT) has been advocated for a long time as a treatment approach and has been extended to include family therapy in the recent years.
Lawrence T, Lam, Mary K, Lam
openaire   +2 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Tangible outcomes of internet use: from digital skills to tangible outcomes project report [PDF]

open access: yes, 2015
In the past decade, digital divide discussions have moved from discussions of use or non-use, to a more nuanced recognition of different types and levels of access, motivation, skills and Internet use in a discourse that centres around digital inclusion ...
Helsper, Ellen J.   +5 more
core  

Diagnostic Criteria for Problematic Internet Use among U.S. University Students: A Mixed-Methods Evaluation.

open access: yesPLoS ONE, 2016
Empirical studies have identified increasing rates of problematic Internet use worldwide and a host of related negative consequences. However, researchers disagree as to whether problematic Internet use is a subtype of behavioral addiction.
Wen Li   +3 more
doaj   +1 more source

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