Results 41 to 50 of about 61,694 (250)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Problematic social media use: associations with health complaints among adolescents.

Annali dell'Istituto superiore di sanita, 2020
Problematic Social Media Use (PSMU) has an addictive potential for young users. The aim of this study was to show the prevalence of PSMU across Italian regions and its association with health complaints.Data are gathered from the Italian 2018 Health Behaviour in School-aged Children survey using a representative sample of Italian adolescents aged 11 ...
Marino C., Lenzi M., Canale N., Pierannunzio D., Dalmasso P., Borraccino A., Cappello N., Lemma P., Vieno A., Nardone P., Spinelli A., Donati S., Pizzi E., Ciardullo S., Andreozzi S., Bucciarelli M., de Mei B., Cattaneo C., Cavallo F., Piraccini G., Berchialla P., Charrier L., Sciannameo V., Gaboardi M., Santinello M., Lazzeri G., Giacchi M. V., Pammolli A., Simi R., Galeone D., Menzano M. T., Vienna A., Colleluori C., Di Giacomo M., Ranalli E., Cauzillo G., Mininni M., Sorrentino G., Azzarito C., Cernuzio A., la Rocca M., Pugliese A., Mazzarella G., Angelini P., Fridel M., Carletti C., Concina F., Ronfani L., Pani P., Cairella G., Bosca L., Pancallo M. T., Ferrando G., Celata C., Coppola L., Lobascio C., Gelmi G., Crottogini L., Velasco V., de Introna S., Giostra G., Ciallella M. L., Colitti M., Paolitto E., Caputo M., Stingi D., Pacella P., Pasquale P., Palmas M. A., Murgia A., Cernigliaro A., Ferro M. P., Scondotto S., Aramini L., Corridori V., Lazzeri G., Cristofori M., Sorbelli D., Giovannini G., Covarino A. M., Michieletto F., Bino E., Zuccali M. G., Fanolla A., Weiss S.   +84 more
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Effect of emotional intelligence on problematic mobile social media use: mediating role of peer relationships and experiential avoidance

Frontiers in Psychology
ObjectiveThe I-PACE model was employed as the theoretical framework to investigate the effect of emotional intelligence on problematic mobile social media use.
Xin Chen, Sifan Peng, Hexu Guan, Huanran Sun, Hongxuan Wu, Xumei Yao, Zi Chen, Xi Yang   +7 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Social media addiction, escapism and coping strategies are associated with the problematic internet use of adolescents in Türkiye: a multi-center study

Frontiers in Psychiatry
IntroductionThe literature highlighted that problematic internet use can have detrimental consequences on individuals’ well-being. Social media addiction, escapism and coping skills are closely related to problematic internet use.
Esen Yildirim Demirdöğen, Mehmet Akif Akinci, Abdullah Bozkurt, Büşranur Bayraktutan, Bahadır Turan, Sevil Aydoğdu, İlknur Ucuz, Elif Abanoz, Gülsüm Yitik Tonkaz, Ali Çakir, Hurşit Ferahkaya   +10 more
doaj   +1 more source

Problematic Use of Internet-Related Activities and Perceived Weight Stigma in Schoolchildren: A Longitudinal Study Across Different Epidemic Periods of COVID-19 in China

Frontiers in Psychiatry, 2021
Background: Social distancing and school suspension due to the coronavirus pandemic (COVID-19) may have a negative impact on children's behavior and well-being.
Xavier C. C. Fung, Andrew M. H. Siu, Marc N. Potenza, Marc N. Potenza, Kerry S. O'Brien, Janet D. Latner, Chao-Ying Chen, I-Hua Chen, I-Hua Chen, Chung-Ying Lin, Chung-Ying Lin, Chung-Ying Lin   +11 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source