Results 71 to 80 of about 702,558 (292)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Attention deficit hyperactivity symptoms predict problematic mobile phone use [PDF]

, 2020
Attention-deficit-hyperactivity disorder (ADHD) is the most commonly diagnosed childhood disorder characterised by inattention, hyperactivity/impulsivity, or both.
A Bianchi, A Dhir, A Enez Darcin, A Tangmunkongvorakul, American Psychiatric Association, CH Ko, CH Ko, CL Crunelle, CL Ventola, E Aboujaoude, E Harstad, E Ophir, E Schoenfelder, F Cao, H Lee, HH Wilmer, HJ Yoo, J Biederman, J Billieux, J De-Sola Gutiérrez, JD Elhai, JD Elhai, JD Parker, JJ Hudziak, JY Mok, JY Yen, JY Yen, K Demirci, KL Smith, L Leung, L Shin, M Beranuy, M Kwon, M Panagiotidi, M Panagiotidi, M Panagiotidi, M Reuter, M Samaha, M Seo, M Shaw, NL Reinsch Jr, NS Hawi, RC Kessler, S Thomée, S Young, SC Cho, SJ Kass, SM Ching, TJ Spencer, VA Pironti, Y Jung, Y Zhang, YK Lee   +52 more
core   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Social media addiction, escapism and coping strategies are associated with the problematic internet use of adolescents in Türkiye: a multi-center study

Frontiers in Psychiatry
IntroductionThe literature highlighted that problematic internet use can have detrimental consequences on individuals’ well-being. Social media addiction, escapism and coping skills are closely related to problematic internet use.
Esen Yildirim Demirdöğen, Mehmet Akif Akinci, Abdullah Bozkurt, Büşranur Bayraktutan, Bahadır Turan, Sevil Aydoğdu, İlknur Ucuz, Elif Abanoz, Gülsüm Yitik Tonkaz, Ali Çakir, Hurşit Ferahkaya   +10 more
doaj   +1 more source

Understanding Problematic Social Media Use in Adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD): A Narrative Review and Clinical Recommendations

Brain Sciences, 2022
Attention-Deficit/Hyperactivity Disorder (ADHD) is consistently associated with a host of social problems, such as victimization and difficulties in maintaining close friendships.
Tycho J. Dekkers, Jorien van Hoorn
doaj   +1 more source

Adolescent social networking: should parents and teachers be worried? [PDF]

, 2011
Over the past few years, there has been a significant increase in the number of media stories about social networking. This has also led to a recent upsurge in the amount of empirical research being carried out.
Griffiths, MD, Kuss, DJ
core  

Magic mirror on the wall: Selfie-related behavior as mediator of the relationship between narcissism and problematic smartphone use [PDF]

, 2019
Objective: Recent research has suggested that problematic smartphone use is associated with several psychological factors and that mobile apps and smartphone-related behavior (i.e. selfi e behavior) may encourage the development of problematic smartphone
Cavani P., Di Blasi M., Giordano C., Lo Coco G., Pavia L., Salerno L., Tosto C.   +6 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source