Results 111 to 120 of about 2,052,150 (308)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Wasted opportunities: Problematic alcohol and drug use among gay men and bisexual men [PDF]

, 2009
This report describes the findings from a qualitative and quantitative study of alcohol and drug use among gay and bisexual men and other men that have sex with men (MSM) in England. The qualitative element describes the experiences and understandings of
Bourne, Adam, Keogh, Peter, Reid, David, Weatherburn, Peter   +3 more
core  

Novel medications for problematic alcohol use

Journal of Clinical Investigation
Alcohol-related harm, a major cause of disease burden globally, affects people along a spectrum of use. When a harmful pattern of drinking is present in the absence of significant behavioral pathology, low-intensity brief interventions that provide information about health consequences of continued use provide large health benefits. At the other end of
Markus Heilig, Katie Witkiewitz, Lara A. Ray, Lorenzo Leggio   +3 more
openaire   +3 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Associations of bullying victimization with problematic internet gaming and problematic social media use among adolescents: moderators and differences

Child and Adolescent Psychiatry and Mental Health
Background Bullying, problematic internet gaming, and problematic social media use are concerning phenomena, especially among youth. However, studies including all three of them are scarce.
Franziska Neumayer, Vanessa Jantzer, Alina Killer, Stefan Lerch, Michael Kaess   +4 more
doaj   +1 more source

Behind the screens: what underlies the experience of social media as a stressor among adolescents

International Journal of Adolescence and Youth
This study explores which aspects of social media use are associated with experiencing it as a stressor among Norwegian adolescents. Data include 3568 participants (aged 16−18), with a longitudinal subsample (n = 432).
Amanda Iselin Olesen Andersen, Turi Reiten Finserås, Gunnhild Johnsen Hjetland, Tormod Bøe, Børge Sivertsen, Jens Christoffer Skogen   +5 more
doaj   +1 more source

OntoKratos: An Ontology for Problematic Smartphone Use Identification and Intervention Suggestion [PDF]

Journal of Universal Computer Science
Smartphone use has increased globally and has become essential in daily life. Although benefits exist, concerns arise about the negative effects of prolonged hyperconnectivity.
Gustavo Lazarotto Schroeder, Wesllei Felipe Heckler, Rosemary Francisco, Jorge Luis Victória Barbosa   +3 more
doaj   +3 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Smartphone addiction, fluid intelligence and working memory in Mexican students

Apertura
The purpose of this article was to determine the association of the level of smartphone addiction with working memory in university students and fluid intelligence in high school graduates.
Ismael Esquivel Gámez , Martín Guerrero Posadas, Julio Cesar Berthely Barrios   +2 more
doaj   +1 more source

Adolescent social networking: should parents and teachers be worried? [PDF]

, 2011
Over the past few years, there has been a significant increase in the number of media stories about social networking. This has also led to a recent upsurge in the amount of empirical research being carried out.
Griffiths, MD, Kuss, DJ
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