Results 31 to 40 of about 101,910 (259)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Den "nøytrale observatørs" rolle ved langvarig observasjon av små grupper [PDF]

, 1976
Artikkel fra boken: "Problemer i samfunnsvitenskapelig ...
Øyen, Else
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Implementering av ABC : en multippel casestudie av utvalgte norske tjenesteytende bedrifter [PDF]

, 2012
Hovedtemaet for denne masterutredningen er aktivitetsbasert kalkulasjon (ABC). Fokuset vil være på problemer knyttet til å implementere ABC. Studien tar utgangspunkt i erfaringer fra fem norske tjenesteytende bedrifter som har implementert ABC og som ...
Grendstadbakk, Ole-Andreas, Gundersen, Cecilie   +1 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Tekstlingvistikkens problemer

Skandinaviske Sprogstudier, 2012
Artiklen tager afsæt i Simon Borchmanns grundlagsdiskussion af tekstlingvistikken i Tekster og sproghandlinger (2010). Han mener, at tekstlingvistikkens hidtidige praksis har været for abstrakt og for lidt pragmatisk.
Ib Ulbæk
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Generasjon prestasjon?

Tidsskrift for Ungdomsforskning, 2019
Artikkelen undersøker hvor mange ungdommer som opplever prestasjons-press på ulike områder og hvor mange som har problemer med å takle presset de står overfor. Et viktig funn er den store variasjonen som finnes mellom ungdom. Et mindretall opplever press
Anders Bakken, forsker II, Mira Aaboen Sletten, forsker II, Ingunn Marie Eriksen, forsker II   +2 more
doaj  

Kan ukrudtet styres, når ploven parkeres? [PDF]

, 2013
Perspektivering over anvendelsen af pløjefri dyrkning i økologisk jordbrug i relation til problemer med ...
Melander, Bo
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source