Results 31 to 40 of about 11,106 (291)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Problemet med problemformuleringer
Dansk Universitetspaedagogisk TidsskriftProblemformuleringen spiller en central rolle i problemorienteret projektarbejde, men studerende opfordres ofte til at formulere den som et spørgsmål – en praksis, der ifølge denne artikel harmonerer dårligt med, hvad det vil sige at formulere et ...
Niels Møller Nielsen +1 more
doaj +1 more source
Receptionsforskningen i Danmark. En oversigt
MedieKultur: Journal of Media and Communication Research, 1988 I de senere år er receptionsforskning et begreb der i stigende grad er gået igen i strømmen af udgivelser på medieområdet. Man kan med rimelighed tale om et paradigmeskifte i dansk medieforskning.
Carsten Y. Hansen
doaj +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Teknologiforståelse og komplekse problemer
, 2022 Teknologiforståelse sigter mod at ruste eleverne i forhold til at møde, håndtere og skabe digital teknologi i deres hverdagsliv, på videre uddannelse og i fremtidige erhverv. Komplekse problemer er omdrejningspunkt for designscenarier i faget, idet evnen
Ejsing-Duun, Stine; id_orcid
core
Professor Morten Sodemann: Der er brug for en tænketank for den tavse klasses problemer
, 2023 Vilde problemer er meningsdannernes og den kreative middelklasses spændende udfordringer – tænk ”Mads og Monopolet” i stor skala. Onde problemer derimod er de mindre velstilledes og frontlinje-medarbejdernes problemer, som har en helt anden konkret og ...
Sodemann, Morten; id_orcid
core +2 more sources
Skandinaviske Sprogstudier, 2012 Artiklen tager afsæt i Simon Borchmanns grundlagsdiskussion af tekstlingvistikken i Tekster og sproghandlinger (2010). Han mener, at tekstlingvistikkens hidtidige praksis har været for abstrakt og for lidt pragmatisk.
Ib Ulbæk
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source