Results 251 to 260 of about 15,396 (289)
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Acta Pharmacologica et Toxicologica, 2009
The electrophysiological effects of procainamide and its major metabolite N-acetylprocainamide were tested and compared on the heart of the anaesthetized dog by means of His bundle electrography and programmed electrical stimulation. Both drugs exerted a
J. Amlie +4 more
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The electrophysiological effects of procainamide and its major metabolite N-acetylprocainamide were tested and compared on the heart of the anaesthetized dog by means of His bundle electrography and programmed electrical stimulation. Both drugs exerted a
J. Amlie +4 more
semanticscholar +1 more source
Clinical Pharmacokinetics of Procainamide
Clinical Pharmacokinetics, 1978Procainamide is almost completely absorbed after oral administration and peak plasma concentrations are generally reached within 1 to 2 hours. Upon intravenous administration there is a rapid initial distribution phase, which is completed after about 30 minutes. The pharmacokinetics can be described by a 2-compartment open model.
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Sustained-Release Procainamide and Neutropenia
Annals of Internal Medicine, 1984Excerpt To the editor: Ellrodt and colleagues (1) recently reported an association between severe neutropenia and the use of sustained-release procainamide.
Scott Anderson, Nanette K. Wenger
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Pharmacokinetic and Pharmacodynamic Interaction of N-Acetyl Procainamide and Procainamide in Humans
Journal of Cardiovascular Pharmacology, 1989Procainamide is a sodium channel blocker which prolongs QRS and QTc intervals, yet its major active metabolite, N-acetylprocainamide (NAPA), generally prolongs only QTc and has very different electrophysiologic and antiarrhythmic actions. In greater than 50% of patients receiving chronic treatment with procainamide, plasma concentrations of NAPA exceed
Dan M. Roden +5 more
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Annals of Internal Medicine, 1984
Excerpt To the editor: Ellrodt and coworkers (1) have performed an important service by calling attention to the problem of neutropenia (granulocytopenia), a known adverse effect of procainamide th...
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Excerpt To the editor: Ellrodt and coworkers (1) have performed an important service by calling attention to the problem of neutropenia (granulocytopenia), a known adverse effect of procainamide th...
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Procainamide‐induced Hemolytic Anemia
Transfusion, 1978The paper reports a case of hemolytic anemia induced by procainamide hydrochloride treatment. Decreases in hemoglobin concentration are correlated with 11 months of procainamide treatment along with a marked increase in hemoglobin following cessation of the drug.
G. W. Jones, R. D. Bradley, T. L. George
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Procainamide-induced psychosis
Critical Care Nurse, 1993The occurrence of procainamide-induced psychosis has not been mentioned previously in the nursing literature and is rarely reported in the medical literature. With the increasing use of procainamide in patients with both atrial and ventricular dysrhythmias, it is quite possible that nurses may encounter the phenomenon more frequently.
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The Effect of Food on Procainamide Absorption
Southern Medical Journal, 1976The effect of food on the absorption characteristics of procainamide was assessed after oral administration of the drug to eight male patients in the fasting and postprandial states. Serum concentration-time curves showed no significant difference in peak serum levels of procainamide, in the time the peak value was reached, or in the area under the ...
Murphy Ml, McKnight Wd
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Effect of verapamil and procainamide on atrial fibrillation-induced electrical remodeling in humans.
Circulation, 1997BACKGROUND Atrial fibrillation (AF) shortens the atrial effective refractory period (ERP) and predisposes to further episodes of AF. The purpose of this study was to determine the effect of verapamil and procainamide on these manifestations of AF-induced
E. Daoud +8 more
semanticscholar +1 more source
Procainamide and Peripheral Neuropathy
Southern Medical Journal, 1981I have described a case of procainamide-induced peripheral neuropathy with a complete resolution after withdrawal of the drug. Extremely close observation is suggested, and if paresthesia and/or polyarthralgias develop, this agent must be withdrawn. The SLE-like syndrome inducted by procainamide completely resolves on withdrawal of the drug.
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