Results 91 to 100 of about 27,479 (263)

The penetration of local anesthetics into phosphatidylcholine monolayers

Journal of Lipid Research, 1976
The penetration of tetracaine into monolayers of phosphatidylcholine and trioctanoin at different surface pressures, and the penetration of dibucaine, tetracaine, butacaine, lidocaine, and procaine into monolayers of didecanoylphosphatidylcholine at Π ...
H S Hendrickson
doaj  

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni, Giulia Galli, Clelia Dallanoce, Marco De Amici, Pau Gorostiza, Carlo Matera   +5 more
wiley   +1 more source

THE ACTION OF PROCAINE AND PROCAINE AMIDE ON THE HEART [PDF]

Heart, 1954
N. A. Wynne, Paul Szekely
openaire   +3 more sources

Fusion of secretory vesicles isolated from rat liver [PDF]

, 1978
Secretory vesicles isolated from rat liver were found to fuse after exposure to Ca2+. Vescle fusion is characterized by the occurrence of twinned vesicles with a continuous cleavage plane between two vesicles in freeze-fracture electron microscopy.
A. Amsterdam, A. Ichikawa, A. Lernmark, A.R. Poole, B. Hellman, B. Rose, C. Miller, C. Schudt, C. Schudt, C.M. Croge, D. Banerjee, D. Branton, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, D. Papahadjopoulos, E.K. Matthews, E.L. Pesanti, F. Malaisse-Lagae, G. Dahl, G. Dahl, G. Dahl, G. Poste, G. Virgilis De, G.M. Grodsky, G.R. Lawford, Gerhard Dahl, H. Schachter, J. Stadler, J.H. Ehrenreich, J.J.M. Bergeron, J.L. Mongar, J.S. Hong, L. Keay, L. Winquist, L.E. Hokin, M. Gratzl, M. Gratzl, M. Gratzl, M. Gratzl, M. Raiteri, M. Redman, M. Reporter, M.G. Farquar, Manfred Gratzl, N.A. Thorn, O. Stein, O.H. Lowry, P. Röhlich, P. Seeman, Q.F. Ahkong, R. Dipolo, R. Ekholm, R. Llinás, R. Miledi, R.C. Baker, R.D. Andrew, R.M. Case, R.P. Rubin, S.J. Burwen, T. Kanno, T. Maeda, T.Ch. Normann, W. Berger, W. Breisblatt, W. Breisblatt, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, W.W. Douglas, Y. Marchand Le   +75 more
core   +1 more source

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

UK National Audit of Early Syphilis Management. Clinics audit: screening for and management of early syphilis [PDF]

, 2006
Data were provided by 131 clinics, and 56% of cases were managed in clinics in the London regions in 2003. Three clinics (2%) do not routinely screen new patients for syphilis, and 28 clinics (21%) do not routinely screen ‘rebook’ patients who have ...
Bunting, P, Carne, C, Daniels, D, McClean, H, Miller, R   +4 more
core   +1 more source

Chronic pain management in a dairy cow with deep digital sepsis

Veterinary Record Case Reports, Volume 13, Issue 2, June 2025.
Abstract This case report describes a cow with a penetrating foreign body in the sole horn of its medial claw of the right forelimb, leading to sequestration and necrosis of the pedal bone and subsequent chronic pain. The surgical interventions, multimodal pain management and development of the gait pattern over more than 6 weeks are described. The cow
Jasmin Laschinger, Johann Kofler
wiley   +1 more source

The Rare Case of a Probably True IgE-Mediated Allergy to Local Anaesthetics

Case Reports in Medicine, 2013
The majority of immediate type adverse reactions to local anaesthetics seem to be non-IgE-mediated. We report a case of a 31-year-old woman, who developed conjunctivitis and conjunctival erythema immediately after intrauterine application of a local ...
Christina Fellinger, Felix Wantke, Wolfgang Hemmer, Gabriele Sesztak-Greinecker, Stefan Wöhrl   +4 more
doaj   +1 more source

Cold heparinized lactated ringers with procaine (HeLP) preservation fluid in 266 living donor kidney transplantations [PDF]

, 2007
Since the 1960s simple inexpensive cold lactated Ringers with additives has been used for short-term cold preservation of kidneys from living donors. We performed 266 living donor kidney transplantations from January 22, 2003 to October 30, 2006.
Ahmad, Amadeo Marcos, Amit Basu, Collins, Collins, Dinesh Vyas, Henkie P. Tan, Hoenicke, Joseph Donaldson, Nirav Shah, Olthoff, Parmjeet Randhawa, Richard L. Simmons, Ron Shapiro, Scantlebury, Sellevold, Tan, Tan, Thomas E. Starzl   +18 more
core   +1 more source

Procaine and Autonomic Innervation

Experimental Biology and Medicine, 1950
ConclusionsProcaine paralyzes first the parasympathetic and later the sympathetic synapses. Procaine suppresses the nicotinic and muscarinic effects of acetylcholine on the heart, but not the muscarinic effect of acetylcholine on the blood vessels. Procaine curarizes first the intercostal respiratory muscles, then the diaphragm and finally the skeletal
D. Atanackovic, Sv. Dalgaard-Mikkelsen
openaire   +3 more sources