Results 41 to 50 of about 4,579,115 (282)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

THE POSSIBILITY OF REDUCTION OF THE FINE COERCIVE BASED ON DUTY TO MITIGATE THE LOSS

Revista Eletrônica de Direito Processual, 2018
The purpose of this study is to analyze the theory of the duty to mitigate the loss and its application in the scope of Brazilian civil procedural law, with special analysis on the coercive fine, using the deductive and interpretative method through ...
Caroline Melchiades Salvadego Guimarães de Souza Lima, Roberto Wagner Marquesi   +1 more
doaj   +1 more source

Clinician and Patient Factors Associated With Long‐Term Glucocorticoid Use in People With Rheumatoid Arthritis Receiving Advanced Therapies

Arthritis Care &Research, EarlyView.
Objective Despite guideline recommendations, long‐term glucocorticoid (GC) use is common in rheumatoid arthritis (RA). We conducted a clinician survey nested within a large registry to identify patient and clinician factors associated with GC use. Methods Clinicians contributing patients to the CorEvitas Rheumatoid Arthritis Registry were surveyed ...
Michael D. George, George Reed, Matthew D. Kearney, Peter F. Cronholm, Kevin Kane, Jeffrey R. Curtis, Dimitrios A. Pappas, Joel M. Kremer   +7 more
wiley   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source

Promoting Healthier Drinking: Evidence From a Vignette Experiment on Contextual and Informational Drivers of Dealcoholized Wine Choices

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Growing demand for healthier beverages is driving innovation in the wine sector, with dealcoholized wine emerging as a promising alternative. However, little is known about the contextual conditions under which consumers would choose dealcoholized wine, particularly in countries with strong wine traditions. To fill this gap, this work examines
Giovanna Piracci, Giulia Maesano, Leonardo Casini, Maurizio Canavari, Marija Cerjak   +4 more
wiley   +1 more source

Constructing and Validating New County‐Level Cultural Capital Indices for Applied Policy Analysis: Evidence From SNAP Take‐Up

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Cultural capital influences a wide range of social and economic outcomes, yet quantitative measures suitable for policy analysis remain limited. We develop county‐level cultural capital indices for the US based on Bourdieu's framework of objectified, embodied, and institutionalized cultural capital.
Pratyoosh Kashyap, Becca B. R. Jablonski, John Bovay   +2 more
wiley   +1 more source

Indigenous Land Ownership and Title in Canada: Implications for a Northern Corridor

The School of Public Policy Publications, 2023
• The proposal to create a Northern Corridor that would allow for cross-country, multi-modal infrastructure development is an ambitious vision (Sulzenko and Fellows 2016; Standing Senate Committee 2017). This proposed infrastructure corridor would
Cherie Metcalf
doaj   +1 more source

Estimation of Import Demand Functions of Two Key Food and Feed Commodities (Corn and Soybean) for India

Agribusiness, EarlyView.
ABSTRACT The derived demand for the increased demand for meat and dairy products is clearly observed in the fast‐paced growth of the Indian feed industry and its increased demand for agricultural commodities (e.g., corn, soybean, rice, wheat, broken rice, millet, etc.) as feed ingredients.
Dwiti Baruah Thapa, Sanjib Bhuyan, Kishor Goswami   +2 more
wiley   +1 more source

Ethnicity and the surgical management of early invasive breast cancer in over 164 000 women

BJS (British Journal of Surgery), EarlyView., 2020
This large national study examined in detail the patterns in surgical management of early breast cancer in women of different ethnicities. Allowing for different patterns of age and stage at presentation, the surgical management of early breast cancer was similar in all women, regardless of ethnicity. All treated the same Background Limited information
T. Gathani, K. Chiuri, J. Broggio, G. Reeves, I. Barnes   +4 more
wiley   +1 more source

Criminal Legal Protection for Bona Fide Third Parties Over Assets in Corruption and Money Laundering Cases

Sriwijaya Law Review
Criminal law in Indonesia has yet to guarantee justice and human rights of bona fide (good faith) third parties in protecting their confiscated assets in corruption and money laundering cases.
Arief Patramijaya
doaj   +1 more source