Results 71 to 80 of about 30,038 (258)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Bounded Regret of a Sequential Procedure for Estimation of the Mean

open access: yesThe Annals of Statistics, 1982
Let $X_1, X_2, \cdots$ be independent observations from a population with mean $\mu$ and variance $\sigma^2$, and suppose that given a sample of size $n$ one wishes to estimate $\mu$ by $\bar{X}_n$, subject to the loss function $L_n = A\sigma^{2\beta-2}(\bar{X}_n - \mu)^2 + n, A > 0, \beta > 0$. If $\sigma$ is known, then the optimal fixed sample size $
Chow, Y. S., Martinsek, A. T.
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

A Sequential Procedure for Selecting the Largest of $k$ Means

open access: yesThe Annals of Mathematical Statistics, 1968
1 online resource (PDF, 9 pages)
Robbins, H., Sobel, Milton, Starr, N.
openaire   +3 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Review of the new facts or new news contained in article 321 of the Chilean Civil Procedure Code

open access: yesBoletín Mexicano de Derecho Comparado
This paper aims to address the procedural figure of new facts or newly discovered events, recognized in some continental Procedure Codes. In this context, we will examine certain historical sources that influenced its modern legislative reception ...
Carlos Alarcón Machuca
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

MEANS OF CRIMINAL PROCEDURAL COGNITION

open access: yesTheory and Practice of Forensic Science and Criminalistics, 2017
The paper deals with the basic means of investigator’s cognition during investigation of a criminal offence. It was clarified that criminal procedural cognition as a process of knowledge formation on factual circumstances of the committed crime, unlike other kinds of human informative activity, occurs in the form ofproving. The relationship of notions «
openaire   +2 more sources

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