Results 61 to 70 of about 189,113 (324)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Advances in semantic representation for multiscale biosimulation: a case study in merging models [PDF]

, 2009
As a case-study of biosimulation model integration, we describe our experiences applying the SemSim methodology to integrate independently-developed, multiscale models of cardiac circulation. In particular, we have integrated the CircAdapt model (written
Arts, Theo, Cook, Daniel L, Gennari, John H, Neal, Maxwell L   +3 more
core   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Procedural Point Cloud and Mesh Editing for Urban Planning Using Blender

Land
Urban planning has become increasingly complex, necessitating the use of digitized data, large-scale city scans, and advanced tools for planning and development.
Gorazd Gorup, Žiga Lesar, Matija Marolt, Ciril Bohak   +3 more
doaj   +1 more source

THE MEDIATING ROLE OF AFFECTIVE COMMITMENT ON THE EFFECT OF PERCEIVED ORGANIZATIONAL SUPPORT AND PROCEDURAL JUSTICE ON JOB PERFORMANCE OF CIVIL SERVANT

Journal of Leadership in Organizations, 2020
This study aims to analyze the mediating role of affective commitment on the effect of perceived organizational support and procedural justice on job performance.
Heru Kurnianto Tjahjono, Meika Kurnia Puji Rahayu, Awang Dirgantara Putra   +2 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Open-Data-Driven Unity Digital Twin Pipeline: Automatic Terrain and Building Generation with Unity-Native Evaluation

Applied Sciences
The creation of simulation-ready digital twins for real-world simulations is hindered by two key challenges: the lack of widely consistent, application-ready open access terrain data and the inadequacy of conventional evaluation metrics to predict ...
Donghyun Woo, Hyunbin Choi, Ruben D. Espejo Jr., Joongrock Kim, Sunjin Yu   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

CodeGen-3D: A Benchmark for Evaluating LLMs in Zero-Shot and Iterative 3D Modeling in Blender

IEEE Access
Large Language Models (LLMs) that generate executable code are opening a new path to text-to-3D by converting natural language prompts into scripts for modeling software like Blender.
Hao Ji, Kotha Aditya, Sebastian Escalante, Yunjian Qiu   +3 more
doaj   +1 more source

Integration of BIM and Procedural Modeling Tools for Road Design

Infrastructures, 2020
Building Information Modeling (BIM) is a design and management methodology strongly used in the Industry of Architecture, Engineering, and Construction (AEC).
Salvatore Antonio Biancardo, Alessandra Capano, Sara Guerra de Oliveira, Andrej Tibaut   +3 more
doaj   +1 more source